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Fluacizine



Fluacizine
Systematic (IUPAC) name
3-diethylamino-1-[2-(trifluoromethyl) phenothiazin-10-yl]-propan-1-one
Identifiers
CAS number 30223-48-4
ATC code  ?
PubChem 161562
Chemical data
Formula C20H21F3N2OS 
Mol. mass 394.455 g/mol
SMILES search in eMolecules, PubChem
Synonyms Flouracizine, Phtorazisin, ftoracizin, 10-(3-(Diethylamino)propionyl)
-2-(trifluoromethyl)phenothiazine, 2-(Trifluoromethyl)-10-
(N,N-diethyl-beta-alanyl)phenothiazine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

-only(US)

Routes Oral, intramuscular

Fluacizine (INN) is an antidepressant with sedative properties derived from phenothiazine.

Fluacizine possesses strong central and peripheral anticholinergic activity.

Additional recommended knowledge

Contents

Uses

Approved

Fluacizine is indicated in bipolar depression, the emotional problems accompanying schizophrenia, anxiety accompanying depression, and for the depressive and extrapyramidal symptoms resulting from neuroleptic therapy. It is not effective for atypical depression or late-onset depression (once known as involutional melancholia).

Side effects

Side effects of fluacizine include feeling of weakness, nausea, and dry mouth.

Contraindications

Fluacizine is contraindicated in patients with liver or kidney impairment, enlarged prostate, peptic ulcer or who have taken MAOIs less than 14 days before starting therapy.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fluacizine". A list of authors is available in Wikipedia.
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