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Dialysis disequilibrium syndrome
In nephrology, dialysis disequilibrium syndrome, commonly abbreviated DDS, is the occurence of neurologic signs and symptoms, attributed to cerebral edema, during or following shortly after intermittent hemodialysis.
Additional recommended knowledge
Classically, DDS arises in individuals starting hemodialysis due to chronic renal failure and is associated, in particular, with "aggressive" (high solute removal) dialysis. However, it may also arise in fast onset, i.e. acute, renal failure in certain conditions.
DDS is a reason why hemodialysis initiation is usually done gradually, i.e. it is a reason the first few dialysis sessions are shorter than is typical in an end-stage renal disease patient.
The cause of DDS is currently not well understood.
There are two theories to explain it; the first theory postulates that urea transport from the brain cells is slowed in chronic renal failure, leading to a large urea concentration gradient, which resulting in reverse osmosis. The second theory postulates that organic compounds are increased in uremia to protect the brain and result in injury by, like in the first theory, reverse osmosis.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dialysis_disequilibrium_syndrome". A list of authors is available in Wikipedia.|