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Covance



Covance
Public (NYSE: CVD)
Founded1997
HeadquartersPrinceton, New Jersey; facilities in 20 countries
Key peopleChairman and CEO: Joseph L. (Joe) Herring
IndustryContract Research Organizations
Pharmaceutical
Productsdrug development services
nutritional testing and analysis
antibody products and services
RevenueUS$1.3 billion USD (2006)
Employees8,100+ (2006)
Websitewww.covance.com

Covance Inc. (NYSE: CVD), formerly Hazleton Laboratories America, Inc., with headquarters in Princeton, New Jersey, provides drug development and animal testing services. According to its website, it is one of the largest companies of its kind in the world, with annual revenues of over $1 billion, operations in 20 countries, and over 8,000 employees worldwide. It provides the world's largest central laboratory network, and employs a global team of clinical trial professionals and cardiac safety experts.[1] It became a publicly traded company after being spun off by Corning, Inc. in 1997.

Under the name Covance Research Products Inc. (CRP), based in Denver, Pennsylvania, the company also deals in the import and sale of laboratory animals. It is the single largest importer of primates in the U.S. and the world's largest breeder of laboratory dogs.[2] It owns two dog-breeding facilities, two primate centers, and a rabbit-breeding facility.

The company has been the subject of controversy following allegations of primate abuse in its laboratories in Germany and the United States, and in connection with a potential outbreak of the Ebola virus.

Additional recommended knowledge

Contents

History of Covance

In the late 1980s and early 1990s, Corning Incorporated acquired numerous best-of-class drug development companies, some with roots dating back to the 1940s. In January 1997, Corning spun off these businesses as one publicly traded, independent company called Covance Inc..

The company's primary focus is serving the pharmaceutical and biotech industries. It provides testing services to the environmental, food, and nutritional supplement industries, and provides custom antibody products and services to the research community for neurological disorders. It also offers cell type-specific marker antibodies for neuroscience; suites of products for both Alzheimer’s and Parkinson’s disease; and an online antibody store including phospho-specific and secondary antibodies.

Ebola virus

  In October 1989, 100 cynomolgus macaques (Macaca fascicularis) were imported from Mindanao Island in the Philippines through Amsterdam and New York to Hazleton Research Products' (now Covance), Primate Quarantine Unit in Reston, Virginia. A second shipment from the same supplier arrived on November 8. Shortly afterwards, some of the monkeys were found to have carried the Ebola virus.[3]

In January 1990, the same Philippines supplier sent a shipment of 100 macaques to Hazleton's Texas Primate Center in Alice, Texas and another 100 Hazleton's Reston Unit. Between February 1 and March 15, 46 of 52 monkeys in one of the quarantine rooms died, showing the same symptoms as before. The Centers for Disease Control decided the monkeys were infected with simian hemorrhagic fever and Ebola.[3]

In March 1996, 100 macaques from the same supplier were shipped to Hazleton in Alice, Texas. Two monkeys tested positive for the Ebola virus.[3][4]

Alleged primate abuse

Münster, Germany

  In 2003, the British Union for the Abolition of Vivisection sent German journalist Friedrich Mülln undercover into the German Covance facility in Münster, Europe's largest primate-testing center. There, Mülln obtained photographs, video, and other evidence of alleged abuse of monkeys and other non-human primates.[5] The laboratory in Münster specializes in reproduction toxicology and primate toxicology, which includes testing on pregnant primates. It is believed to be one of the largest users of non-human primates in Europe.[6]

The undercover footage shows staff making monkeys dance in time to blaring pop music, handling them roughly, and screaming at them. The monkeys are shown isolated in small wire cages with little or no natural light and no environmental enrichment, and living with high noise levels caused by staff shouting and playing the radio.[7] In response, Covance maintained that clips showing different technicians working in different buildings had been edited together, resulting in a sequence of events that did not take place.[8]

Primatologist Dr. Jane Goodall described the living conditions of the monkeys as horrendous.[7] "To see a monkey alone in a cage like that, with nothing to do so that they go completely crazed with boredom and sadness probably, it's deeply, deeply disturbing."[6] Primatologist Stephen Brend told BUAV that using monkeys in such a stressed state is "bad science" and that trying to extrapolate useful data in such circumstances is an "untenable proposition."[7]

The ensuing publicity in Germany gave rise to the "Close Covance" (Covance Schliessen) animal rights campaign there, as well as campaigns launched in Britain by the BUAV, and in America by PETA. Nature reported that the company was in danger of losing its licence.[5]

According to the European Biomedical Research Association, the local authorities in Munster inspected Covance after the video footage was shown on German television, and insisted that Covance install video cameras to monitor staff working with primates.[8] Covance appealed through the courts, which decided that video monitoring would infringe the rights of the staff. The public prosecutor's office also viewed the film and questioned witnesses. The prosecutor's office concluded that Covance "had not rendered themselves liable to prosecution," thus clearing the company of all charges.[8]

After parts of Mülln's footage were shown on German television and in major newspapers, Covance filed a lawsuit, leading a German court to forbid further distribution of the material. The publication ban led to major protests from animal-rights advocates and anti-censorship activists. A first ruling confirming Covance's claims was partially reverted by a higher court's ruling that the right of the public to be informed on the subject prevailed over the company's privacy rights. The video footage may now be displayed publicly, albeit not in the form of the existing television edition, but it may not be used by animal-rights groups.

Vienna, Virginia

Animal testing

Main articles
Animal testing
Alternatives to animal testing
Testing on: invertebrates ·
Frogs · Primates · Rabbits · Rodents
Animal testing regulations
History of animal testing
History of model organisms
Laboratory animal sources
Toxicology testing

Issues
Biomedical Research
Animal rights/Animal welfare
Animals (Scientific Procedures) Act
Great ape research ban
International trade in primates

Controversial experiments
Britches · Brown Dog affair
Cambridge University primates
Pit of despair
Silver Spring monkeys
Unnecessary Fuss

Companies
Charles River Laboratories, Inc.
Covance · Harlan
Huntingdon Life Sciences
UK lab animal suppliers
Nafovanny · Shamrock

Groups/campaigns
Americans for Medical Progress
AALAS · AAAS
Boyd Group · BUAV
Dr Hadwen Trust · PETA
Foundation For Biomedical Research
National Anti-Vivisection Society
Physicians Committee
for Responsible Medicine
Primate Freedom Project
Pro-Test · SPEAK
Research Defence Society
Stop Huntingdon Animal Cruelty

Writers/activists
Colin Blakemore · Carl Cohen
Gill Langley · Ingrid Newkirk
Neal Barnard · Jerry Vlasak
Simon Festing · Tipu Aziz

Categories
·

Related templates
Template:Animal rights

This box: view  talk  edit

  People for the Ethical Treatment of Animals (PETA) found similar conditions in Covance's Vienna, Virginia lab during an undercover investigation in 2004-5.[9]

A former study director at the Covance facility in Vienna, Virginia in the U.S., who worked there from 2002 to 2004, told city officials in Chandler, Arizona, that Covance was dissecting monkeys in its Vienna laboratory while the animals were still alive and able to feel pain.

The allegations were uncovered as part of an open-records request made by PETA in November 2006. The employee had earlier approached the city with her concerns when she learned that Covance planned to build a new laboratory in Chandler. [2]

She alleged that three monkeys in the Vienna laboratory had pushed themselves up on their elbows and had gasped for breath after their eyes had been removed, and while their intestines were being removed during necropsies. When she expressed concern at the next study directors' meeting, the employee says she was told that it was just a reflex. She told city officials that she believed such movements were not reflexes but suggested "botched euthanasia performed by inadequately trained personnel." She says that she was ridiculed and subjected to thinly veiled threats when she contacted her supervisors about the issue.[10]

In June 2005, Covance filed a lawsuit against PETA and its former employee for fraud, breach of employee contract, and "conspiracy to harm the company's business by deceitfully infiltrating and videotaping the company's Vienna, Virginia facility." Covance and PETA agreed to a settlement in which PETA accepted a five-year ban on any attempts to infiltrate Covance facilities. [11]

In a March 2006 statement, Covance announced that inspections of the Vienna, Virginia facility by the Food & Drug Administration (FDA) “resulted in no findings to substantiate any claims made against the facility.” Inspections by the United States Department of Agriculture (USDA) resulted in sixteen citations ranging, according to Covance, from "administrative issues to scope of veterinary authority." The company agreed to pay a settlement of $8,720. [3]

Expansion

In recent years, Covance continued its expansion with acquisitions of drug development companies. Notably, in August 2005, Covance acquired GFI Clinical Services, an 80-bed clinical pharmacology business, from West Pharmaceutical Services, Inc. in order to expand the company’s Phase I clinical research offerings. [4]

In May 2006, Covance also acquired Signet Laboratories, Inc., which is a provider of monoclonal antibodies used in the research of cancer, infectious disease and neurodegenerative disease. [5]

See also

  • Animal testing
  • Nafovanny
  • Non-human primate experiments
  • International primate trade

Notes

  1. ^ Covance website.
  2. ^ Pippin, John. "Covance Gets an 'F' in Social-Responsibility Test", Chandler Republic, August 26, 2006; reproduced by the Physicians Committee for Responsible Medicine.
  3. ^ a b c Waterman, Tara. "Ebola Reston Outbreaks", Human Virology at Stanford.
  4. ^ "TDH Schedules Briefing on Investigation into Monkeys with Ebola", Texas Department of State Health Services, April 15, 1996.
  5. ^ a b Schiermeier, Quirin. "Primate lab faces closure threat over mistreatment charge", Nature, 427, 4, January 1, 2004.
  6. ^ a b "Inside Covance: BUAV/ECEAE launches first ever undercover investigation in an animal testing laboratory in Germany", Europäische Koalition zur Beendigung von Tierversuchen.
  7. ^ a b c Video hosted on PETA website
  8. ^ a b c European Biomedical Research Association Covance cleared of primate charges, accessed August 18, 2007.
  9. ^ "Covance photo gallery", People for the Ethical Treatment of Animals.
  10. ^ "Former Study Director Reports Hideous, Systematic Cruelty at Covance; PETA Calls For Federal Investigation of Alleged Atrocities", People for the Ethical Treatment of Animals, November 28, 2006.
  11. ^ "Covance Prevails in PETA Lawsuit; Court Enters Order Requiring PETA to Comply With Ban on Infiltration"
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Covance". A list of authors is available in Wikipedia.
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