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Complement deficiency

Complement deficiency
Classification & external resources
ICD-10 D84.1
ICD-9 279.8
OMIM 217000 120820, 120900, 610102
DiseasesDB 1847 1869, 1873, 7384, 34381
eMedicine med/419  ped/447

Complement deficiency is a condition of absent or suboptimal functioning of one of the complement system proteins.

The disorders can be divided into two categories:

  • Disorders of the proteins which act to activate the complement system (such as C3) can lead to an underactive response, causing greater susceptibility to infections.

Because there are redundancies in the immune system, many complement disorders are never diagnosed. A recent study estimated that less than 10% are identified.[1]

See also


  1. ^ Sjöholm AG, Jönsson G, Braconier JH, Sturfelt G, Truedsson L (2006). "Complement deficiency and disease: an update". Mol. Immunol. 43 (1-2): 78-85. PMID 16026838.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Complement_deficiency". A list of authors is available in Wikipedia.
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