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Aminophylline



Aminophylline
Systematic (IUPAC) name
1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Identifiers
CAS number 317-34-0
ATC code R03DA05
PubChem 9433
DrugBank APRD00329
Chemical data
Formula C16H24N10O4 
Mol. mass 420.427 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 60%
Metabolism  ?
Half life 7-9 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

P(UK)

Routes oral, i.v.

Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

Additional recommended knowledge

Properties

It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.

Mechanism of action

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.

Brand names

  • Phyllocontin
  • Truphylline
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aminophylline". A list of authors is available in Wikipedia.
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