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Alpha 2-antiplasmin

Alt. Symbols PLI
Entrez 5345
HUGO 9075
OMIM 262850
RefSeq NM_000934
UniProt P08697
Other data
Locus Chr. 17 pter-p12

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins.


Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alpha_2-antiplasmin". A list of authors is available in Wikipedia.
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