Bipolar Disorder

Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect gene expression, i.e., transcription of genes for the purpose of translation more

A global study conducted by the international "Brainstorm Consortium" has, for the first time, analysed the genome of 1.1 million patients with psychiatric and neurological disorders and has shown that certain brain disorders are genetically related. For example, there is a significant correlation b more

Circadian rhythms are regular 24-hour variations in behaviour and activity that control many aspects of our lives, from hormone levels to sleeping and eating habits. In the largest ever genetic study of circadian rest-activity cycles in humans, scientists at the University of Glasgow have identified more

by Kumaresan Jayaraman, Alex N. Morley, Daniel Szöllősi, Tjerk A. Wassenaar, Harald H. Sitte, Thomas Stockner The human dopamine transporter (hDAT) is located on presynaptic neurons, where it plays an essential role in limiting dopaminergic signaling by temporarily curtailing high neurotransmitte more

Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase, COX) of the mitochondrial electron transport chain have been implicated in the pathophysiology of major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), as well as more

We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some more