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7 Current white paper about the topic breast cancer
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Mutation Scanning Using High Resolution Melting or dHPLC: a Performance Comparison Study
21-12-2009
Introduction High Resolution Melting (HRM) is a novel and promising screening technique used for mutation analysis and detection. Its application prevents the need to sequence all the exons of a gene when looking for novel mutations. The method is therefore time- and cost-effective for the ...
Outstanding Microarray Experimental Results Using FuGENE® HD Transfection Reagent
03-06-2009
Introduction Transfection is a method for delivering nucleic acids, either DNA or RNA, into animal cells in vitro. In applications such as protein production, the main purpose is to produce protein; consequently any effects on endogenous gene expression are generally irrelevant, unless the ...
The xCELLigence System: Label-Free Measurement of Natural Killer Cell Cytotoxic Activity in Real Time
19-08-2008
Introduction Natural killer (NK) cells have been implicated in the recognition and annihilation of tumor cells. The assessment of the cytolytic activity of NK cells is important not only for monitoring of immunocompetence in cancer, infectious diseases, and autoimmune diseases, but also in ...
Aphidicolin-Mediated Replication Stress Induces Submicroscopic Tumor-Like Deletions in FHIT/FRA3B
26-05-2008
Introduction Common fragile sites (CFSs) are loci that are particularly susceptible to forming gaps and breaks on metaphase chromosomes after partial inhibition of DNA synthesis, for example induced by aphidicolin (APH). FRA3B, a fragile site lying within the FHIT tumor suppressor gene, is a ...
Rapid High-Throughput Methylation Analysis Using the LightCycler® 480 System
07-05-2008
The LightCycler® 480 Instrument is a versatile platform for molecular studies. We assessed the performance of the instrument combined with the LightCycler® 480 High Resolution Melting Master mix for DNA methylation analysis using the methylation-sensitive high resolution melting (MS-HRM) ...
Analysis of the DNA Methylation Patterns at the BRCA1 CpG Island
20-08-2007
Introduction Germ-line alterations of the BRCA1 gene confer a lifetime risk of 40% for ovarian cancers and of 40%-80% for breast cancers. It is likely that BRCA1 acts as a tumor suppressor gene. BRCA1 involvement in breast cancers does not seem to be restricted to familial cancers. Despite ...
Quantification of BRCA1 Expression Level Using Standard RT-PCR Reagents - a Sensitive Method for the Detection of Low Amounts of Transcripts
17-08-2007
Mutations in the breast cancer susceptibility gene, BRCA1, occur in the majority of families with multiple members affected with breast or ovarian cancer. Women who inherit a BRCA1 mutation have 40%–80% risk of developing breast cancer or ovarian cancer. However, up to 90% of breast cancers ...
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