Genome Sequences

News Genome Sequences

• Watermelon genome decoded

  Sweeter and more disease-resistant watermelons just may be on their way, thanks to an international consortium of more than 60 scientists that has just published the genome sequence of watermelon (Citrullus lanatus). Such information could dramatically accelerate breeding to produce more nutritious, more

• Stanford researchers first to determine entire genetic sequence of individual human sperm

  The entire genomes of 91 human sperm from one man have been sequenced by Stanford University researchers. The results provide a fascinating glimpse into naturally occurring genetic variation in one individual, and are the first to report the whole-genome sequence of a human gamete — the only cells t more

• Tomato genome gets fully sequenced

  For the first time, the genome of the tomato, Solanum lycopersicum, has been decoded, an important step toward improving yield, nutrition, disease resistance, taste and color of the tomato and other crops.The full genome sequence, as well as the sequence of a wild relative (Solanum pimpinellifolium) more

White papers Genome Sequences

• The New Genome Sequencer FLX System
  

  In 2005, the Genome Sequencer 20 System was introduced into the global life science market. Based on the revolutionary 454 sequencing technology, this system is able to generate hundreds of thousands of sequence reads in a few hours at a fraction of costs compared with the traditional Sanger technology. more

• Array Capture-mediated Resequencing Leads to the Discovery of Four Novel Mutations in the Mouse
  

  By using array-based sequence capture and pyrosequencing to sequence an allelic series from the classically defined Kit locus (~200 kb) from each of five noncomplementing Kit mutants (one known allele and four unknown alleles), D'Ascenzo and co-workers discovered and validated a nonsynonymous coding mutation for each allele. These data represent the first documentation and confirmation of the fact that the new technologies can be used to efficiently discover causative mutations. Importantly, these results also provide the framework for constructing the efficient detection of causative mutations in mutant mouse strains moving forward. The standards presented here, coupled with the latest sequence capture methods (e.g., whole-exome arrays or solution-based methods) and next-generation sequencing technologies, promise to signicantly close the gap between phenotype and genotype in the mouse more

• Identification of a New Arenavirus Using High-Throughput Sequencing
  

  Culture, PCR, serologic, and oligonucleotide microarray analyses for a wide range of infectious agents were negative in samples from three individuals who had received organ transplants from a single donor and died of a febrile illness 4-6 weeks after transplantation. Palacios et al. used high-troughput sequencing with the Genome Sequencer FLX system to identify microbial sequences from RNA samples taken from the liver and kidney transplants in two recipients. They found 14 sequences representing an Old World arenavirus related to lymphocytic choriomeningitis viruses. more

Publications Genome Sequences

• Gene Duplication Is Infrequent in the Recent Evolutionary History of RNA Viruses

  Gene duplication generates genetic novelty and redundancy and is a major mechanism of evolutionary change in bacteria and eukaryotes. To date, however, gene duplication has been reported only rarely in RNA viruses. Using a conservative BLAST approach we systematically screened for the presence of d more

• PpeTAC1 promotes the horizontal growth of branches in peach trees and is a member of a functionally conserved gene family found in diverse plants species

  Summary Trees are capable of tremendous architectural plasticity, allowing them to maximize their light exposure under highly competitive environments. One key component underlying tree architecture is the branch angle. Yet, little is known about the molecular basis for spatial patterning of bra more

• Adaptive Mutations and Replacements of Virulence Traits in the Escherichia coli O104:H4 Outbreak Population

  by Lionel Guy, Cecilia Jernberg, Jenny Arvén Norling, Sofie Ivarsson, Ingela Hedenström, Öjar Melefors, Ulrika Liljedahl, Lars Engstrand, Siv G. E. Andersson The sequencing of highly virulent Escherichia coli O104:H4 strains isolated during the outbreak of bloody diarrhea and hemolytic uremic syn more

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