Includes new features and tools to increase productivity, result and confidence in DSC data for use in regulated biopharmaceutical discovery and development more
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MicroCal PEAQ-DSC Automated – PEAQ-Compliance for 21 CFR Part 11 compliant operation and data analysis
MicroCal PEAQ-DSC Automated – PEAQ-Performance to ensure optimal system operation
MicroCal PEAQ-DSC Automated – PEAQ-Smart for SOP-based operation and automated analysis
MicroCal PEAQ-DSC Automated – PEAQ-Compare for the direct comparison of DSC thermograms
MicroCal PEAQ-DSC Automated
Differential scanning calorimetry is an established biophysical tool for the characterization of protein stability. A protein's stability is a critical quality attribute which is characterized throughout biopharmaceutical drug discovery and development, to help decide if it should be chosen to advance in the pipeline, and to help guide selection of the process and formulation conditions needed to maintain its stability.
In a DSC system, the protein in solution is placed in the DSC cell and heated at a constant rate, resulting in the protein unfolding due to thermal denaturation. The protein’s heat capacity (Cp) changes as the protein denatures. The peak of a DSC thermogram represents the protein's thermal transition midpoint (TM). For a protein which reversibly denatures, TM is the temperature where 50% of the protein is in its native (folded) conformation, and 50% is in its denatured (unfolded) conformation. TM is considered a good indication of thermal stability – the higher the TM, the more thermally stable the protein.
The MicroCal PEAQ-DSC Automated system has new features and improvements designed to improve productivity during biopharmaceutical discovery and development, generating high-quality, reproducible, and reliable DSC data which can be used for regulatory submissions. MicroCal PEAQ-DSC Automated systems are essential additions to the 'biophysical toolbox' in biopharma, CROs and CDMOs, and core facilities at academic and government research laboratories.
SOPAT GmbH announced a distribution agreement with Malvern Panalytical. Malvern Panalytical is now the exclusive distributor for a complete range of SOPAT photo-optical image analysis instrumentation and software in the United States of America. “We are thrilled to be working together with ... more
Spectris plc announces that effective 1 January 2017, Malvern Instruments and PANalytical will be merging their activities. Both Malvern and PANalytical are operating companies within the Materials Analysis segment of Spectris. The companies are both world leading suppliers of analytical in ... more
Malvern announced PENSABIO Biotechnology as a new partner acting as an Exclusive Representative in Brazil to product lines MicroCal, NanoSight, Archimedes, Zetasizer Helix and Viscosizer TD. Therefore, from 2016, the Pensabio now assumes the sale process (Pre and Post), Services, Technical ... more
Malvern Panalytical technologies are used by scientists and engineers in a wide range of industries and organizations to solve the challenges associated with maximizing productivity, developing better quality products and getting them to market faster. Our mission is to create superior, cus ... more