Sartorius AG
English
42 Minutes
Validation of Covalent Immune Recruiters (CIRs) with Synthetic Tumor Immunotherapeutic Applications
Learning Objectives:
• Discover novel trifunctional CIRs that can selectively label serum antibodies and direct immune responses to specific target proteins
• Use of label-free binding assays to obtain kinetic information to quantify covalent labeling of antibodies and evaluate selectivity
• Monitoring target protein binding and antibody recruitment under relevant equilibrium conditions
• Validation of CIRs specificity and selectively in vivo
Topics: antibodies, binding kinetics, blood cancer, cancer cells, cytotoxicity, BLI, biomolecular interaction analysis, biosensor, label-free, mAb, serum proteins, tumor immmunotherapy