RedShift BioAnalytics, Inc.
English
41 Minutes
Advancing Structural Characterization of Therapeutic Proteins Using MMS
Researchers at Amgen analyzed monoclonal antibodies (mAbs) using Microfluidic Modulation Spectroscopy (MMS) at concentrations ranging from 0.5 to 50 mg/mL and obtained superior data by optimizing detector dwell time settings. MMS generates reproducible data with high sensitivity at low formulation concentrations and is a more reliable and cost-effective method for evaluating secondary structure vs traditional IR techniques.
Topics: biopharmaceuticals, circular dichroism, monoclonal antibodies, protein analysis, protein characterization, Biophysical methods, Biotherapeutic formulation, Biotherapeutic quality analysis, Fournier transform infrared, Higher order structure, Microfluidic modulation spectroscopy, Mid-infrared spectroscopy, Protein secondary structure, Protein similarity, Structural characterization, high sensitivity, low concentration, mAb analysis, mAbs
