“Aging Clock” reveals aging processes in immune cells

Research team creates AI-based computer model that makes aging visible at the cellular level for the first time

20-Mar-2025 - Not only does our body change with age, but so does our immune system. A recent study led by the Centre for Individualised Infection Medicine (CiiM) shows exactly how immune cells age and how infections and vaccinations can influence this process. The CiiM is a joint initiative of the Helmholtz ...

Tuberculosis research: promising new active agent

A novel antibiotic

13-Jan-2025 - Tuberculosis is the most common infectious disease worldwide. In the year 2022 alone, there were 10.6 million new infections and 1.3 million deaths. “We urgently need an effective new drug to fight tuberculosis, especially in view of the growing problem of antibiotic-resistant strains,” says ...

Tuberculosis Strains Resistant to New Drugs Are Transmitted Between Patients

“We must stay ahead in this constant race between drug development and bacterial resistance...”

08-Jan-2025 - Tuberculosis (TB) is the world’s biggest infectious disease killer with multidrug-resistant TB (MDR-TB) posing a particular threat to global health. A study led by the Swiss Tropical and Public Health Institute (Swiss TPH) shows that resistance to the new MDR-TB treatment regimen recently ...

Reckoned without one's host: Transmission of tuberculosis does not only depend on the pathogen

Geographical overlap between pathogen and host has a measurable influence on the transmissibility of the tuberculosis pathogen

06-Aug-2024 - Different groups of TB bacteria exist worldwide with different regional distribution: some are generalists and can be found on many continents, others are very limited in their spread. An international team of researchers has now been able to show for the first time that the specialist strains ...

Novel compounds promise success in the fight against tuberculosis and depression

14-Dec-2023 - Prof. Bernd Plietker and his research group at the Chair of Organic Chemistry I at TUD have specifically developed a class of natural substances - polyprenylated polycyclic acylphloroglucinols (PPAP for short). Due to its properties, the resulting derivative PPAP53 is characterized by great ...

Breaking bad barriers through a molecular vacuum cleaner

27-Oct-2023 - A molecular vacuum cleaner Triglycerides are the form in which fat energy is stored in our tissue. “Mycobacteria also accumulate triglycerides,” explains Lars Schäfer. “But in addition to store energy, these molecules are also a key component that contributes to seal their cellular barrier.” This ...

Evotec receives US$ 6.6 m grant for drug discovery in tuberculosis

24-Mar-2023 - Evotec SE announced that the Company has received a US$ 6.6 m grant from The Bill & Melinda Gates Foundation for drug discovery in tuberculosis (“TB”). The grant is the second award from the foundation to Evotec supporting TB drug discovery, and allows the Company to progress a portfolio of TB ...

Seeing concentrations of toxins with the naked eye

New test detects compounds for disease diagnostics, environmental monitoring

07-Nov-2022 - Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a fast and cost-effective method to test liquids for a ubiquitous family of chemical compounds known as amphiphiles, which are used to detect diseases such as early-stage tuberculosis and ...

Point-of-care diagnostics for multiple diseases, courtesy of photonics technology

New generation of diagnostic systems

21-Mar-2022 - COVID 19 has turned PCR and other antigen tests from tools known only to medical professionals into an everyday experience for all of us. To mark the successful completion of their research on the PoC-BoSens platform, the project consortium led by Fraunhofer IZM can announce the birth of a new ...

A Trojan horse against tuberculosis

New transport route for antibiotics directly into infected cells

14-Jun-2021 - Tuberculosis is still the infectious disease that is responsible for the highest number of deaths worldwide. It is caused by Mycobacterium tuberculosis, a bacterium that infects cells in the lungs. There, the pathogen is hardly accessible to most antibiotics. In addition, resistance to existing ...