99 million people included in largest global COVID-19 vaccine safety study

Global Vaccine Data Network utilises vast data sets to detect potential vaccine safety signals

27-Feb-2024 - The Global Vaccine Data Network (GVDN) assessed 13 neurological, blood, and heart related medical conditions to see if there was a greater risk of them occurring after receiving a COVID-19 vaccine. This was one of eight studies in the Global COVID Vaccine Safety (GCoVS) Project. Recently ...

Can education and occupation influence cardiovascular health and mortality?

05-Oct-2023 - Researchers of the Department of Cardiology – Cardiology I at the University Medical Center Mainz have shown that people with low socioeconomic status (SES) had a higher risk of developing a cardiovascular disease. They also had an increased risk of death. Educational attainment and employment ...

Co-crystal improves the water-solubility of ASA

This could benefit patients diagnosed with suspected acute myocardial infarction

15-Sep-2023 - For decades, researchers have been looking for ways to make the active ingredient acetylsalicylic acid (ASA) – the active ingredient of Aspirin – more water-soluble. It’s used not only as pain relief, but also to prevent the formation of life-threatening blood clots in heart attacks and strokes. ...

The Paradox of Thrombosis

18-Apr-2023 - Bears in hibernation and also paraplegic people spend months or even years lying almost motionless. In healthy people, however, bedriddenness is always accompanied by the risk of thrombosis. A paradox, but nevertheless an everyday occurrence. This contradiction has now been investigated by an ...

The influenza virus and its influence on blood stem cells and coagulation

Local respiratory infection with flu viruses activates dormant blood stem cells in the bone marrow

20-Oct-2022 - Virus-induced respiratory infections can become life-threatening. A team at the Paul-Ehrlich-Institut, together with researchers in Heidelberg, have discovered that flu virus infection limited to the lungs also leads to the activation of blood stem cells and the increased formation of platelets. ...

Patented molecules that counteract the effect of the most common anticoagulant drug

CSIC researchers identify molecules that reverse the anticoagulant effect of heparin, used to treat patients at risk of blood thrombi

11-Mar-2022 - A study carried out by scientists at the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) of the Spanish National Research Council (CSIC) has discovered and synthesized several molecules that inhibit the effect of the most common anticoagulant drug. This drug is very useful for treating ...

TargED Biopharmaceuticals raises EUR 39 Million to bring groundbreaking thrombolytic treatment to patients

Funds will accelerate development of first-in-class targeted thrombolytic treatment into clinical development

28-Feb-2022 - TargED Biopharmaceuticals, a private biotechnology startup focused on developing improved treatments for thrombotic diseases, announces it has raised Series A financing of EUR 39 million to accelerate development of its lead compound, Microlyse. The financing was led with equal contribution by an ...

Specific control molecule in platelets identified

Starting point for drug development against thrombosis, heart attack and stroke

12-Aug-2020 - The previously largely unknown molecule bridging integrator 2 (BIN2) plays a central role in platelet activation, as researchers from Würzburg have now shown in a joint project of the DFG Collaborative Research Centre/Transregio 240. This finding provides indications of starting points for drug ...

Multiple roles of glucose metabolism in platelet activation and survival identified

07-Aug-2017 - Platelets, the cells in blood that enable clotting, are highly reliant on their ability to metabolize glucose, according to a new study by researchers at the University of Iowa. The findings may have implications for understanding the increased risk of thrombosis--blood clots inside blood ...

A new ligand extends the half-life of peptide drugs from minutes to days

18-Jul-2017 - Peptides are biological molecules, made up of short sequences of amino acids. Because they are easy to synthesize, show low toxicity and high efficiency, peptides such as insulin and other hormones can be used as drugs. But peptides are quickly cleared by the kidneys, which means that we can only ...