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Telomerase

News Telomerase

  • Going with the DNA flow: Molecule of life finds new uses in microelectronics

    For sheer versatility, there's no molecule quite like DNA. The iconic double-helix carries the genetic blueprint for living forms ranging from single-celled organisms to human beings. Recently, researchers have found that DNA's remarkable properties of self-assembly and its ability to conduct electr more

  • By decoding how HPV causes cancer, researchers find a new potential treatment strategy

    A study that teases apart the biological mechanisms by which human papillomaviruses (HPV) cause cancer has found what researchers at Georgetown University Medical Center say is a new strategy that might provide targeted treatment for these cancers. HPV is responsible for the majority of cervical can more

  • New insights into latent HIV infections

    In spite of ever more effective therapies, HIV keeps managing to survive in the body. A comprehensive project conducted by the Austrian Science Fund FWF has clarified the molecular processes which contribute to this effect. In the process, approaches were discovered for possible therapies to combat more

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White papers Telomerase

  • Nobel Prize for Solving the End-Replication Problem

    The Nobel Assembly awarded this year's Nobel Prize in Medicine to Elizabeth H. Blackburn, Jack W. Szostak, and Carol W. Greider for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. With their ingenious genetic re more

Publications Telomerase

  • Histone depletion prevents telomere fusions in pre-senescent cells

    by Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M. Muñoz-Cabello, Félix Prado Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during more

  • Telomerase can't handle the stress [Outlook]

    Telomerase counteracts the telomere shortening that occurs with each round of cell division. In normal human cells, telomerase is repressed, leading to telomere shortening that triggers replicative senescence. However, in most tumors, telomerase is up-regulated and is essential for telomere mainten more

  • PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase [Research Papers]

    Telomerase counteracts telomere shortening and cellular senescence in germ, stem, and cancer cells by adding repetitive DNA sequences to the ends of chromosomes. Telomeres are susceptible to damage by reactive oxygen species (ROS), but the consequences of oxidation of telomeres on telomere length a more

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Related topics
Definition

Telomerase

Telomerase Telomerase is an enzyme that adds specific DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' ("three prime") end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes . The telomer ... more

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