Synthesis

Companies Synthesis

iCD. Vertriebs GmbH, Germany

iCD. is an ISO 9001 certified company and premium supplier of software solutions for laboratory automation since 1986. More than 300 large-scale to mid-size companies of different industry sectors such as pharma/biotechnology, chemical/petrochemical, food/beverage, cosmetics and automotive, worldwid more

Products Synthesis

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

Preparative HPLC: Flexibility Meets Convenience

The unique Azura prep HPLC systems: Multifunctional preparative HPLC systems you can easily adapt to specific sample purification challenges more

Look up Industrial Syntheses of 2,600 APIs

One-stop source of information relating to the industrial synthesis and commercial applications of every licensed drug of significance more

News Synthesis

• Learning from Nature’s Bounty: New Libraries for Drug discovery
  

  Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult to emulate and build on Nature’s success in the laboratory. By completin more

• Development of an Efficient Enantioselective Desymmetrization Strategy Using Recombinant Pig Liver Esterases
  

  An economically significant process intensification for the efficient enzymatic synthesis of (1S,2R)-1-(methoxycarbonyl) cyclohex-4-ene-2-carboxylic acid was achieved by a careful adaption of the reaction mode to minimize mass transfer limitations. (1S,2R)-1-(methoxycarbonyl) cyclohex-4-ene-2-carbox more

• Breakthrough reveals new ways to combat drug-resistant bacteria and fight cancer
  

  After 20 years of dedicated research, scientists have cracked the chemical code of an incredibly complex 'anti-tumour antibiotic' known to be highly effective against cancer cells as well as drug-resistant bacteria, and have reproduced it synthetically in the lab for the first time. This major break more

Videos Synthesis

Aspirin

In this video about aspirin we show you an old sample and make a new one. more

Preparative HPLC: Flexibility Meets Convenience

For the successful purification of samples, you ideally want to handle large sample volumes conveniently and have the flexibility to perform different purification tasks. Whether in synthesis or for APIs, the modular AZURA prep HPLC systems from KNAUER are your perfect solution. That’s because prepa more

Focused Microwave Synthesis with CEM Systems

Single-Mode Cavity Design At the heart of the new Discover System resides the technology which makes it so unique. The patented circular single-mode cavity design directs the microwave energy into a defined area, resulting in a homogenous field pattern surrounding the sample. "Focusing" the microwav more

White papers Synthesis

• Analysis of water soluble polymers using linear size exclusion HPLC columns and a semi-micro SEC system
  

  One of the most widely used water-soluble polymers is Polyvinylpyrrolidone (PVP). For more than 70 years it is applied in a variety of applications in medicine, pharmacy, cosmetics and industrial production. PVP binds to polar molecules exceptionally more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to more

• qPCR Identification of Genes Involved in Apoptosis and Cell Cycle Regulation
  

  Systematic high-throughput functional genomic screens with the targeted silencing of genes by the introduction of small interfering RNA (siRNA) have emerged as an extremely powerful tool for analysis of biological functions. Such screens commonly res more

Publications Synthesis

• Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method

  Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave reactor in t more

• Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification [ARTICLE]

  N6-threonyl-carbamoyl adenosine (t6A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t6A stabilizes the codon–anticodon interaction and hence promotes translation fidelity. The first step of the biosyn more

• Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

  by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we demonstrate more