Synthesis

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Preparative HPLC: Flexibility Meets Convenience

The unique Azura prep HPLC systems: Multifunctional preparative HPLC systems you can easily adapt to specific sample purification challenges more

Where Are Your Limits? With Berghof High-Pressure Reactors More Flexibility in Synthesis

The modular design and flexible configuration options of Berghof highpreactor are a convincing response to the requirements of modern synthesis laboratories more

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

News Synthesis

• A new strategy for the synthesis of complex natural products
  

  Chemists from the University of Basel have succeeded in synthesizing two complex natural products from the group of dithiodiketopiperazines (DTPs). For this, they employed a new strategy based on “C-H bond activation,” resulting in a short and high yielding route. In the of the Journal of the Americ more

• Chemicals for pharmaceuticals could be made cheaper and greener by new catalysts

  High value chemicals used to make pharmaceuticals could be made much cheaper and quicker thanks to a series of new catalysts made by scientists at the University of Warwick in collaboration with GoldenKeys High-Tech Co., Ltd. in China. The process of making high-value chemicals for uses such as the more

• Let there be light: Synthesizing organic compounds
  

  Every biological reaction is a chemical reaction. The exchange of carbon dioxide for oxygen in our lungs and blood cells, for example, is caused by molecules releasing chemicals and reforming with new ones. The uncontrolled replication of cancerous cells is the result of broken chemical compounds mi more

Videos Synthesis

Where Are Your Limits? With Berghof High-Pressure Reactors More Flexibility in Synthesis

The modular design and flexible configuration options of Berghof highpreactor are a convincing response to the requirements of modern synthesis laboratories. Safety, reliability and economy are achieved through the use of high-quality materials combined with durable PTFE linings. Complete PTFE Linin more

Aspirin

In this video about aspirin we show you an old sample and make a new one. more

Preparative HPLC: Flexibility Meets Convenience

For the successful purification of samples, you ideally want to handle large sample volumes conveniently and have the flexibility to perform different purification tasks. Whether in synthesis or for APIs, the modular AZURA prep HPLC systems from KNAUER are your perfect solution. That’s because prepa more

White papers Synthesis

• qPCR Identification of Genes Involved in Apoptosis and Cell Cycle Regulation
  

  Systematic high-throughput functional genomic screens with the targeted silencing of genes by the introduction of small interfering RNA (siRNA) have emerged as an extremely powerful tool for analysis of biological functions. Such screens commonly res more

• Analysis of water soluble polymers using linear size exclusion HPLC columns and a semi-micro SEC system
  

  One of the most widely used water-soluble polymers is Polyvinylpyrrolidone (PVP). For more than 70 years it is applied in a variety of applications in medicine, pharmacy, cosmetics and industrial production. PVP binds to polar molecules exceptionally more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to more

Job offers Synthesis

• Quality Assurance Specialist (m/f/d)
  

  SEQENS is an integrated global leader in pharmaceutical synthesis and specialty ingredients, delivering outstanding performance, unrivalled market responsiveness and tailor-made solutions to our customers. SEQENS operates 24 manufacturing plants and 3 R&D centers in Europe, North America and Asia wi more

Publications Synthesis

• Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method

  Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave reactor in t more

• Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification [ARTICLE]

  N6-threonyl-carbamoyl adenosine (t6A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t6A stabilizes the codon–anticodon interaction and hence promotes translation fidelity. The first step of the biosyn more

• Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

  by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we demonstrate more