Synthesis

Products Synthesis

Connectivity at its best - Upgrade your laboratory

Unified user interface, operation in network and on mobile devices, multiple users in parallel ✓ Extremely fast temperature conditioning and high temperature stability thanks to RapidTemp ✓ Easy sample supply, smallest sample volumes, smart accessories, modular system more

Look up Industrial Syntheses of 2,600 APIs

One-stop source of information relating to the industrial synthesis and commercial applications of every licensed drug of significance more

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

News Synthesis

• Tiny sensors for major advances
  

  An international research team involving the working group of biophysicist Dr. Manuel Etzkorn from Heinrich Heine University Düsseldorf (HHU) has developed an approach for using NMR spectrometry to analyse important molecules that have not been accessible before now. In the journal Angewandte Chemie more

• Breakthrough in the production of three-dimensional molecular structures
  

  A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected in c more

• How to use antibodies to control chemical reactions
  

  Antibodies are remarkable biomarkers: they are the cues that provide us with indications about many diseases and how our immune system counter them. Now a group of scientists from the University of Rome, Tor Vergata (Italy) has found a way to repurpose them so that they can trigger a specific chemic more

Videos Synthesis

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

CEM Corporation is transforming the way chemists perform peptide synthesis once again with the introduction of the Liberty Blue microwave peptide synthesizer. With 4 minute cycle times and a 90% solvent reduction, no other peptide synthesizer on the market can even come close to the performance of t more

Preparative HPLC: Flexibility Meets Convenience

For the successful purification of samples, you ideally want to handle large sample volumes conveniently and have the flexibility to perform different purification tasks. Whether in synthesis or for APIs, the modular AZURA prep HPLC systems from KNAUER are your perfect solution. That’s because prepa more

Aspirin

In this video about aspirin we show you an old sample and make a new one. more

White papers Synthesis

• RealTime ready RT-qPCR Assay Development and Qualification
  

  On the RealTime ready Configurator, we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL). The Universal ProbeLibrary is a set of short hydrolysis pro more

• alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
  

  The alamarBlue® cell proliferation assay is based on a reducing environment that indicates metabolic active cells. Active cells are able to convert resazurin into the resorufin. Resazurin is blue and non-fluorescent whereas resorufin is red and highl more

• RealTime ready qPCR Assay Design and Configuration Portal Content
  

  The gene and transcript annotational content of the RealTime ready Configurator offers a combined view of three of the main gene annotation authorities. The positional information of the lab-tested RealTime ready assays regarding transcript or exon c more

Publications Synthesis

• Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method

  Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave reactor in t more

• Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification [ARTICLE]

  N6-threonyl-carbamoyl adenosine (t6A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t6A stabilizes the codon–anticodon interaction and hence promotes translation fidelity. The first step of the biosyn more

• Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

  by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we demonstrate more