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Preparative HPLC: Flexibility Meets Convenience

The unique Azura prep HPLC systems: Multifunctional preparative HPLC systems you can easily adapt to specific sample purification challenges more

Look up Industrial Syntheses of 2,600 APIs

One-stop source of information relating to the industrial synthesis and commercial applications of every licensed drug of significance more

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

News Synthesis

• Bioactive natural compounds for the fight against cancer
  

  Phytoalexins are bioactive phytochemicals that have attracted much attention in recent years due to their health-promoting effects in humans and their vital role in plant health. Chemists at TU Dresden have now developed a new and very efficient synthesis for these substances. With the new method, t more

• Environmentally friendly production of mandelic acid
  

  Sometimes potentially useful enzymes are not easy to discover because their biocatalytic capabilities may go beyond their natural and thus known range of action. By recombining a newly discovered enzymatic capability, a research team from the Max Planck Institute for Terrestrial Microbiology led by more

• Making Puffer Fish Toxin in a Flask
  

  In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the journ more

Videos Synthesis

Preparative HPLC: Flexibility Meets Convenience

For the successful purification of samples, you ideally want to handle large sample volumes conveniently and have the flexibility to perform different purification tasks. Whether in synthesis or for APIs, the modular AZURA prep HPLC systems from KNAUER are your perfect solution. That’s because prepa more

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

CEM Corporation is transforming the way chemists perform peptide synthesis once again with the introduction of the Liberty Blue microwave peptide synthesizer. With 4 minute cycle times and a 90% solvent reduction, no other peptide synthesizer on the market can even come close to the performance of t more

Aspirin

In this video about aspirin we show you an old sample and make a new one. more

White papers Synthesis

• alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
  

  The alamarBlue® cell proliferation assay is based on a reducing environment that indicates metabolic active cells. Active cells are able to convert resazurin into the resorufin. Resazurin is blue and non-fluorescent whereas resorufin is red and highl more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to more

• RealTime ready RT-qPCR Assay Development and Qualification
  

  On the RealTime ready Configurator, we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL). The Universal ProbeLibrary is a set of short hydrolysis pro more

Publications Synthesis

• Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method

  Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave reactor in t more

• Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification [ARTICLE]

  N6-threonyl-carbamoyl adenosine (t6A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t6A stabilizes the codon–anticodon interaction and hence promotes translation fidelity. The first step of the biosyn more

• Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

  by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we demonstrate more