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Structural Biology

News Structural Biology

  • Substantial differences between the tumor-promoting enzymes USP25 and USP28 identified

    Researchers from the Rudolf Virchow Center of the University of Würzburg (JMU) have solved the structures of the cancer-promoting enzymes USP25 and USP28 and identified significant differences in their activities. Both enzymes promote the growth of various tumors. The results were published in the j more

  • How a small molecule promotes removal of excess cholesterol

    Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver. The research reveals how a drug-like chemical stimulates the action of the lecithin:cholesterol acyltransferase (LCAT) enzyme. It also suggests that future drugs using th more

  • Images of antibodies working together against malaria

    Scientists investigating how the human immune system defends against malaria have uncovered a rare phenomenon: antibodies working together to bind to a vulnerable spot on the parasite. The new research shows that antibodies working together can result in a protein on the parasite's cell surface lock more

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Videos Structural Biology

How can structural biology help to fight flu?

This short video explains how structural biology can be used to help fight influenza. The clip, which was developed by ELLS in collaboration with EMBL Grenoble scientists working on the EU-funded Flupharm project, is a great tool to introduce students to the topics of influenza, infectious disea ... more

Understanding Crystallography - Part 1: From Proteins to Crystals

How can you determine the structure of a complex molecule from a single crystal? Professor Elspeth Garman take us on a journey into the world of crystallography - from protein production and purification to growing the right type of crystals.In her laboratory at the University of Oxford Elspeth ... more

Understanding Crystallography - Part 2: From Crystals to Diamond

How do X-rays help us uncover the molecular basis of life?In the second part of this mini-series, Professor Stephen Curry takes us on a journey into the Diamond Light Source, one of the UK's most expensive and sophisticated scientific facilities.Generating light brighter than the sun, and hostin ... more

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Publications Structural Biology

  • Tackling microtubule-tau interactions

    Structural Biology Alzheimer's disease is a major cause of death in the elderly. Disease progression is associated with the accumulation of neurofibrillary tangles composed of tau, a protein important for neuronal development and function. Tangle formation is preceded by phosphorylation events that more

  • Edge cases cause trouble

    Structural Biology Single-particle cryo–electron microscopy detects macromolecules trapped in a thin layer of vitreous ice. High-resolution, accurate reconstructions benefit from randomly arranged and well-dispersed particles, but biological samples do not always cooperate. Noble et al. used cryo more

  • Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser [Biophysics and Computational Biology]

    X-ray Free-Electron Lasers have opened the door to a new era in structural biology, enabling imaging of biomolecules and dynamics that were impossible to access with conventional methods. A vast majority of imaging experiments, including Serial Femtosecond Crystallography, use a liquid jet to delive more

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Definition

Structural biology

Structural biology Structural biology is a branch of molecular biology concerned with the study of the architecture and shape of biological macromolecule s—protein s and nucleic acid s in particular—and what causes them to have the ... more

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