Steroids

News Steroids

• Study ends debate over role of steroids in treating septic shock

  The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year. Researchers at The George Institute for Global Health studied whether the use of steroids as an additional treatmen more

• Streamlined process opens drug development to a new class of steroids

  Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process facilitates access to rare, mirror-image isomers of naturally occurring steroid structures. The technique, based on a series of new che more

• Reasons not to lick a toad
  

  As human diseases become alarmingly antibiotic resistant, identification of new pharmaceuticals is critical. The cane toad and other members of the Bufonidae family produce substances widely used in traditional folk medicine, but endangered family members, like Panama's golden frog, Atelopus zeteki, more

White papers Steroids

• GC-C-IRMS Determination of Hormones
  

  By amending methodology to utilize eVol® for sample preparation processes for GC-C-IRMS C isotope ratio analysis, the ISORA department has: improved sample preparation conditions and the GC-C-IRMS analysis results by removing the risk of ghost peaks, more

Infographics Steroids

The Chemistry Behind the Russian Doping Scandal – in C&EN

The run-up to the Rio Olympics has been overshadowed by a number of issues, not least of which is the doping scandal surrounding Russian competitors. This month’s Periodic Graphics in C&EN looks at the alleged chemical cocktail that was used to dope Russian athletes at the 2012 London Games and in t more

Publications Steroids

• C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis [Microbiology]

  Sterols are essential eukaryotic lipids that can be preserved as steroids in sedimentary rocks for billions of years. Because eukaryotes are the predominant modern day producers of these lipids, fossilized sterols are used as geological biomarkers for the presence of specific eukaryotes in ancient e more

• Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract

  Steroid-refractory (SR) acute gastrointestinal (GI) graft-versus-host disease (GVHD) is associated with significant mortality in allogeneic hematopoietic cell transplantation recipients. We retrospectively evaluated the efficacy of tocilizumab for the treatment of SR biopsy-proven acute lower GI GVH more

• The window of improved neonatal respiratory compliance after rescue antenatal steroids

  To evaluate whether premature infants delivered ≤7 days after rescue antenatal steroid treatment (ideal treatment) have increased passive respiratory compliance compared to those delivered >7 days after treatment (remote treatment). Secondary analysis of a randomized trial of rescue antenatal steroi more