Tumor profiling: 43,000 data points against melanoma

Data-driven personalized treatments are about to become a reality

06-Jun-2025 - Every tumor is unique. This makes it difficult to find the most effective therapy for treatment. The Tumor Profiler Center of the University Hospital Zurich, the University of Zurich, ETH Zurich and the University Hospital Basel has now carried out a study in which nine different molecular ...

Skin cancer: mode of action of combination immunotherapy decoded

Why a long-established combination therapy against black skin cancer works better than the individual active ingredients

03-Jan-2025 - A study by the University Medical Center Freiburg shows why certain combined immunotherapies can help patients with advanced skin cancer particularly well. The two immune checkpoint therapies prevent the tumor from switching off the immune cells. As the Freiburg researchers have now been able to ...

Joint research on the next generation of sun screens

The German Cancer Research Center (DKFZ) and Beiersdorf are cooperating on the development of innovative sun protection products

16-Dec-2024 - Experts predict that climate change and the associated increase in the number of hours of sunshine will lead to a further increase in skin cancer cases. This is particularly to be expected for non-melanoma skin cancer, which is diagnosed around 210,000 times in Germany every year. This term ...

Skin flora as the key to cancer therapy?

22-Aug-2024 - Can the skin microbiome, also known as skin flora, influence the effectiveness of cancer therapy? Dr. Robin Reschke from the Department of Dermatology at Heidelberg University Hospital (UKHD) and the National Center for Tumor Diseases (NCT) in Heidelberg wants to find out. German Cancer Aid is ...

The Mechanism Behind Melanoma Resistance to Treatment

Findings could pave the way for more effective therapies

01-Jul-2024 - In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings could pave the way for more effective therapies. Malignant melanoma ...

Sophisticated mechanism revealed: Cells inherit protection from sunburn

Stress granules protect cells from the effects of UV radiation

22-Mar-2024 - UV radiation in the sunlight causes sunburn and increases the risk of skin cancer by damaging our DNA but also our RNA. Researchers at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany, have now unveiled a cellular shield that protect cells from the harmful effects of ...

AI-based support system for skin cancer diagnostics explains its decisions

The explanations increased doctors' confidence in the machine's decisions - as well as in their own diagnoses

19-Jan-2024 - Artificial intelligence (AI) can help dermatologists to detect skin cancer. However, many dermatologists distrust the algorithms' decisions, which they cannot comprehend. Scientists at the German Cancer Research Center have now developed an AI-based support system for skin cancer diagnostics that ...

Skin rejuvenation for cancer prevention

Turning back the epigenetic clock in skin cells: DKFZ and Beiersdorf establish Joint Innovation Lab

05-Jul-2023 - Rejuvenating skin and preventing skin cancer: That is the vision of the scientists at the new Joint Innovation Lab, which Beiersdorf and the German Cancer Research Center (DKFZ) founded on July 1, 2023. In the jointly operated lab, researchers are taking a close look at the "epigenetic clock" of ...

In cells, UV-emitting nail polish dryers damage DNA and cause mutations

The ultraviolet nail polish drying devices used to cure gel manicures may pose more of a public health concern than previously thought

19-Jan-2023 - Researchers at the University of California San Diego studied these ultraviolet (UV) light emitting devices, and found that their use leads to cell death and cancer-causing mutations in human cells. The devices are a common fixture in nail salons, and generally use a particular spectrum of UV ...

Brain metastases in melanoma patients: important molecular mechanisms decoded

Different cell states determine progression of the disease

05-Jan-2023 - The development of brain metastases is a frequent occurrence in melanoma that is associated with a poor prognosis for the affected patients. The effectiveness of existing therapies varies greatly. The reasons for this variability, however, remain largely unknown. An international research team ...