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Sickle Cell Disease

News Sickle Cell Disease

  • CRISPR-Cas9 corrects sickle cell mutation

    Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects must be minimized to mitigate risks that may arise from the unintended action of more

  • Progress in pursuit of sickle cell cure

    Scientists have successfully used gene editing to repair 20 to 40 percent of stem and progenitor cells taken from the peripheral blood of patients with sickle cell disease, according to Rice University bioengineer Gang Bao. Bao, in collaboration with Baylor College of Medicine, Texas Children's Hosp more

  • Lego proteins revealed

    When hemoglobin undergoes just one mutation, these protein complexes stick to one another, stacking like Lego blocks to form long, stiff filaments. These filaments, in turn, elongate the red blood cells found in sickle-cell disease. For over 50 years, this has been the only known textbook example in more

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Definition

Sickle-cell disease

Sickle-cell disease Sickle-cell disease (SS) is a group of genetic disorders caused by sickle hemoglobin (Hgb S or Hb S). In many forms of the disease, the red blood cell s change shape upon deoxygenation because of polymerization of the abn ... more

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