How ApoE4 endangers the brain
Apolipoprotein E4 is considered the most important genetic risk factor for Alzheimer’s disease. A group of researchers, led by MDC scientist Thomas Willnow, has now discovered how ApoE4 can damage the brain.
Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It ... more
Fantastic muscle proteins and where to find them
Setting out to identify all proteins that make up the sarcomere, the basic contractile unit of muscle cells, resulted in an unexpected revelation, providing experimental evidence that helps explain a fundamental mystery about how muscles work. The research was published in Nature Communicat ... more
Overactive enzyme causes hereditary hypertension
After more than 40 years, several teams at the MDC and ECRC have now made a breakthrough discovery with the help of two animal models: they have proven that an altered gene encoding the enzyme PDE3A causes an inherited form of high blood pressure. This could lead to new concepts for the tre ... more