Nanoplasmid™ Vector Platform

• Smaller backbone. Stronger results. Unlock higher expression and cleaner performance from the start
• Remove complexity at the source. Simplify development with an antibiotic‑free, streamlined vector design
• De-risk your path to the clinic. Built to align with modern regulatory expectations
• Upgrade without losing momentum. Transition from conventional plasmids—no restart required
• Scale with confidence. Proven performance from research through cGMP manufacturing

Improve expression, simplify development, and move faster to clinic with next-generation DNA design.

The Nanoplasmid™ Vector System is an advanced DNA backbone engineered to deliver higher performance and greater reliability in genomic medicine. Its ultra‑compact, antibiotic free design enables efficient, reproducible outcomes—while aligning with modern regulatory expectations.

Nanoplasmid™ vectors continue to deliver standout performance across nonviral programs, and the latest data coming out of recent studies has been particularly strong.

Researchers using Nanoplasmid™ vector technology are reporting:

· CRISPR: Up to 90% editing efficiency

· Transposon delivery: Up to 97% integration efficiency

· Direct vector delivery: Up to 10× higher transgene expression

· CAR-T (clinical): 100% overall response rate (vs. 50–67% with standard plasmids)

Delve into cutting-edge research featuring Nanoplasmid™ vectors and discover how, and where Nanoplasmid™ vector technology is driving the biggest impact across cell and gene therapy.

Engineered for performance

Higher transgene expression compared to conventional plasmids

Improved editing efficiency and more consistent outcomes

Enhanced cell viability across applications

Designed to simplify complexity

Removes unnecessary bacterial elements

Eliminates antibiotic resistance genes

Reduces regulatory, manufacturing, and operational burden

Built for scale and confidence

cGMP-ready platform from research through clinical manufacture

Backed by Aldevron’s global quality systems and regulatory expertise

Proven across multiple development programs

One vector. Endless possibilities.

Nanoplasmid™ vectors are designed to unlock better performance—without adding complexity.

Higher and more reliable editing efficiency

Improved functional outcomes

Stronger safety profile (no antibiotic resistance genes)

Scalable, consistent manufacturing performance

From early research through cGMP, Aldevron supports customized Nanoplasmid™     vector solutions to help advance the next generation of cell and gene therapies.

Retrofit advantages

A simple way to upgrade performance without starting over.

Guided design plan with Aldevron experts

Lower development risk than designing and building from scratch

Faster access to improved expression and safety benefits

Applicable across research, preclinical, and cGMP programs