Novel way to identify still unknown pathogens

Evolutionary trade-offs: Balancing genetic disease risks and pathogen protection

02-Feb-2023 - Certain genes can exist in different, functionally divergent variants in the individuals of a species. If they lead to clear differences, for example in a phenotype or susceptibility to disease, this is known in biology as a polymorphism. Typical examples are a number of genes whose variants are ...

Potential cause for lupus identified

17-Jul-2017 - Leading rheumatologist and Feinstein Institute for Medical Research Professor Betty Diamond, MD, may have identified a protein as a cause for the adverse reaction of the immune system in patients suffering from lupus. A better understanding of how the immune system becomes overactive will help ...

Purdue-based startup develops software to reduce drug discovery losses

More accurate and less expensive drug structure prediction

19-Aug-2016 - A Purdue-based startup is developing molecular modeling simulation software that could help pharmaceutical companies more accurately predict the crystal structure of a drug once produced, helping maintain a consistent drug quality and save costs when developing new drugs. Lyudmila Slipchenko, ...

Antisocial behaviour: Understanding the influence of genes and the environment

13-Jan-2016 - A gene involved in the regulation of emotions and behaviour could influence the long-term impact of violence experienced in childhood on antisocial behaviour. This is the finding of a longitudinal study carried out by a team of researchers at the Institut universitaire en santé mentale de ...

Oyster genome uncover the stress adaptation and complexity of shell formation

21-Sep-2012 - An international research team, led by Institute of Oceanology of Chinese Academy of Sciences and BGI, has completed the sequencing, assembly and analysis of Pacific oyster (Crassostrea gigas) genome — the first mollusk genome to be sequenced — that will help to fill a void in our understanding ...

Enzyme deficiency protects hepatitis C patients from treatment-related anemia

23-Feb-2010 - Many people who undergo treatment for hepatitis C develop hemolytic anemia, a disorder that destroys red blood cells. In some cases, it is so severe they have to reduce their medication or stop therapy altogether. But now, scientists in Duke University's Institute for Genome Sciences & Policy ...

Right first time: Pioneering new methods of drug manufacture

13-Nov-2009 - Engineers at the University of Leeds have developed a simple technology which can be used in existing chemical reactors to ensure "right first time" drug crystal formation. Ensuring drug crystals are formed correctly is crucial to their efficacy and the efficiency of pharmaceutical manufacturers' ...

Polymorphisms of the interleukin-1 gene complex may influence alcohol dependence

22-Sep-2009 - Cytokines are small proteins secreted by cells that serve as molecular messengers between cells. Pro-inflammatory cytokines – which function in the immune system – may be involved in alcohol dependence (AD). A study of three polymorphisms of the interleukin-1 gene complex (IL-1) and one of the ...

Scientists reshape Y chromosome haplogroup tree gaining new insights into human ancestry

02-Apr-2008 - The Y chromosome retains a remarkable record of human ancestry, since it is passed directly from father to son. In an article published in Genome Research, scientists have utilized recently described genetic variations on the part of the Y chromosome that does not undergo recombination to ...

Scientists in Spain Develop a Panel of Genetic Markers for Tracing Meat from Farm to Fork

Researchers collaborate with Applied Biosystems to validate specific genetic polymorphisms for identifying individual pigs from commercial breeds

11-Dec-2007 - Scientists at the Universitat Autònoma de Barcelona, Spain, have developed and validated an identity test that can be used to confirm the breed and origin of meat from farm animals. The test was developed in collaboration with Applied Biosystems , an Applera Corporation business, and uses a ...