Polymorphism

News Polymorphism

• Potential cause for lupus identified

  Leading rheumatologist and Feinstein Institute for Medical Research Professor Betty Diamond, MD, may have identified a protein as a cause for the adverse reaction of the immune system in patients suffering from lupus. A better understanding of how the immune system becomes overactive will help lead more

• Purdue-based startup develops software to reduce drug discovery losses

  A Purdue-based startup is developing molecular modeling simulation software that could help pharmaceutical companies more accurately predict the crystal structure of a drug once produced, helping maintain a consistent drug quality and save costs when developing new drugs. Lyudmila Slipchenko, associ more

• Antisocial behaviour: Understanding the influence of genes and the environment

  A gene involved in the regulation of emotions and behaviour could influence the long-term impact of violence experienced in childhood on antisocial behaviour. This is the finding of a longitudinal study carried out by a team of researchers at the Institut universitaire en santé mentale de Montréal ( more

White papers Polymorphism

• The Characterization of Pharmaceuticals Using Thermal Analysis
  

  The guide was designed to support thermal analysis (TA) users with real examples of the most relevant applications pertinent to the pharmaceutical industry more

• Adaptation of SmartAmp-2 Assays for Microsatellite Copy Number Polymorphism Detection on the LightCycler® 480 Instrument
  

  The Smart Amplification process, version 2 (SMAP-2), also known as SmartAmp-2, is a rapid polymorphism detection system based on a unique asymmetric primer design, including a folding primer (FP) and a turn-back primer (TP) [1]. Combined with Thermus more

Infographics Polymorphism

The Polymorphs of Chocolate

With Easter upcoming, here’s another graphic on chocolate to go with the previous food chemistry graphic which looked at some of the chemicals it contains. This one examines the different structures of chocolate, why the tempering process is important to produce the highest quality chocolate – and w more

Publications Polymorphism

• Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares

  Snowshoe hares (Lepus americanus) maintain seasonal camouflage by molting to a white winter coat, but some hares remain brown during the winter in regions with low snow cover. We show that cis-regulatory variation controlling seasonal expression of the Agouti gene underlies this adaptive winter cam more

• Dissociable contributions of the amygdala to the immediate and delayed effects of emotional arousal on memory [RESEARCH]

  Emotional arousal enhances memory encoding and consolidation leading to better immediate and delayed memory. Although the central noradrenergic system and the amygdala play critical roles in both effects of emotional arousal, we have recently shown that these effects are at least partly independent more

• Dissociable contributions of the amygdala to the immediate and delayed effects of emotional arousal on memory [RESEARCH]

  Emotional arousal enhances memory encoding and consolidation leading to better immediate and delayed memory. Although the central noradrenergic system and the amygdala play critical roles in both effects of emotional arousal, we have recently shown that these effects are at least partly independent more