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Pfizer and BioNTech Announce Early Positive Data from an Ongoing Phase 1/2 Study of mRNA-based Vaccine Candidate Against SARS-CoV-2

Efforts to manufacture the leading candidates, at risk, are gearing up

02-Jul-2020

Pfizer Inc. and BioNTech SE announced preliminary U.S. data from the most advanced of four investigational vaccine candidates from their BNT162 mRNA-based vaccine program, Project Lightspeed, against SARS-CoV-2, the virus causing the current global pandemic. The BNT162 program is evaluating at ...

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Researchers identify multiple molecules that shut down SARS-Cov-2 polymerase reaction

A library of molecules with unique structural and chemical features inhibit the novel coronavirus polymerase, a key drug target for COVID-19

02-Jul-2020

SARS-CoV-2, the coronavirus causing the global COVID-19 pandemic, uses a protein called polymerase to replicate its genome inside infected human cells. Terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host's immune ...

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analytica 2020: Great exhibitor resonance for the autumnal fair

Trade fair to implement the government’s protection and hygiene concept

30-Jun-2020

After the postponement to the fall, there are now increasing signs for a success of analytica in October. The number of exhibitors has currently almost reached the level of the previous event. Most recently, the Bavarian State Government has cleared the way for analytica: From September 01 ...

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X-rays size up protein structure at the 'heart' of COVID-19 virus

The protease protein is both shaped like a heart and functions as one, allowing the virus to replicate and spread

30-Jun-2020

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. The X-ray measurements mark an important first step in the ...

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The dangerous dual role of the immune system in COVID-19

Immune cells occasionally overshoot the mark and, due to their excessive reaction, sometimes cause greater damage than the virus itself

29-Jun-2020

Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin ...

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Merck initiates clinical Covid-19 study

First clinical trial of TLR7 and 8 inhibitor as a potential treatment for severe symptoms of Covid-19 infection

26-Jun-2020

Merck announced the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application (IND) for M5049 for the treatment of patients with Covid-19 pneumonia. Merck will initiate a Phase II randomized, controlled clinical study evaluating the safety and efficacy of M5049 ...

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The tricks of the immune system

How the T-cell response changes in chronic virus infections

26-Jun-2020

More than half of the world's population is infected with the cytomegalovirus. The majority of people don't even notice the infection, since their immune systems keep the virus in check. Groups of T cells with a variety of virus-specific receptors play a key role in this process. Now researchers ...

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CSIC researchers will use a type of 'coronavirus parasite' to combat it

A project studies specific forms of coronavirus parasites to interfere with the replication capacity of SARS-CoV-2 and promote its elimination

23-Jun-2020

A team of researchers from the Spanish National Research Council (CSIC) is leading a project to develop antiviral drugs to prevent the replication of the SARS-CoV-2 coronavirus, which caused the Covid-19 pandemic. The study focuses on the so-called DIPs (Defective Interfering Particles), a common ...

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Scientists produce first open source all-atom models of full-length COVID-19 'S' protein

The protein structure facilitates viral entry into host cells making it a key target for vaccine and antiviral drug development

23-Jun-2020

The virus SARS coronavirus 2 (SARS-CoV-2) is the known cause of coronavirus disease 2019 (COVID-19). The "spike" or S protein facilitates viral entry into host cells. Now a group of researchers from Seoul National University in South Korea, University of Cambridge in UK, and Lehigh University in ...

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Cellular nanosponges could soak up SARS-CoV-2

A nanoparticle decoy with the virus' natural targets lure SARS-CoV-2 away from cells

22-Jun-2020

Scientists are working overtime to find an effective treatment for COVID-19, the illness caused by the new coronavirus, SARS-CoV-2. Many of these efforts target a specific part of the virus, such as the spike protein. Now, researchers reporting in Nano Letters have taken a different approach, ...

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