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18 Current news about the topic pluripotency

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Tracking protein’s role in stem cell function

26-Mar-2018

MCL-1 is a member of the BCL-2 family of proteins important for blocking apoptosis, or programmed cell death. Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1. However, new evidence from Vanderbilt University researchers indicates that MCL-1 also helps ...

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First stem cells using CRISPR genome activation created

22-Jan-2018

In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important ...

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Genetic cross-talk key to cell balance

07-Jun-2017

Competing regulatory genes "talk" to each other to maintain balance of cell state, according to new research from the Stowers Institute for Medical Research. In a study Stowers scientists Bony De Kumar, Ph.D., and Robb Krumlauf, Ph.D., provide evidence of direct cross-regulatory feedback, or ...

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Why stem cells need to stick with their friends

11-Nov-2013

Scientists at University of Copenhagen and University of Edinburgh have identified a core set of functionally relevant factors which regulates embryonic stem cells' ability for self-renewal. A key aspect is the protein Oct4 and how it makes stem cells stick together. The identification of these ...

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Singapore Scientists Discover New RNA Processing Pathway Important in Human Embryonic Stem Cells

12-Sep-2013

Scientists at A*STAR's Genome Institute of Singapore (GIS), in collaboration with their counterparts from Canada, Hong Kong and US, have discovered a protein mediator SON plays a critical role in the health and proper functioning of human embryonic stem cells (hESCs). This finding was reported in ...

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Learning from the linker

New study sheds light on cellular reprogramming

07-Feb-2013

Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie ...

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MIT researchers develop a better way to grow stem cells

23-Aug-2010

Human pluripotent stem cells, which can become any other kind of body cell, hold great potential to treat a wide range of ailments, including Parkinson's disease, multiple sclerosis and spinal cord injuries. However, scientists who work with such cells have had trouble growing large enough ...

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RNA offers a safer way to reprogram cells

New technique could revert cells to immature state that can develop into any cell type

28-Jul-2010

In recent years, scientists have shown that they can reprogram human skin cells to an immature state that allows the cells to become any type of cell. This ability, known as pluripotency, holds the promise of treating diseases such as diabetes and Parkinson's disease by transforming the patients' ...

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Virus-free technique enables Stanford scientists to easily make stem cells pluripotent

09-Feb-2010

Tiny circles of DNA are the key to a new and easier way to transform stem cells from human fat into induced pluripotent stem cells for use in regenerative medicine, say scientists at the Stanford University School of Medicine. Unlike other commonly used techniques, the method, which is based on ...

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New research shows versatility of amniotic fluid stem cells

25-Nov-2009

For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought. Reporting in ...

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