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22 Current news about the topic opioids


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Activation of opioid receptor uncovered


Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor. The results facilitate the development of new active substances. The opioids used today to treat severe pain can be ...


The pharmacological “fingerprint“ of the fourth opioid receptor


Pharmacologists from Jena, Toulouse, St. Louis and Boca Raton as well as Montreal, Seattle and Mountain View were able to decipher the molecular behavior of the nociceptin receptor in cells and intact animals. Now published in Science Signaling, their research paper on the investigation of the ...


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Preclinical study suggests path toward non-addictive painkillers


A pre-clinical study led by Indiana University scientists reports a promising step forward in the search for pain relief methods without the addictive side effects behind the country's current opioid addiction crisis. The research finds that the use of compounds called positive allosteric ...


From heroin addiction to alcohol-related problems


Methadone programs and long-term therapy using other opioids evidently work. People addicted to heroin consume less heroin, cocaine and even alcohol at the beginning of the treatment. As a long-term study conducted by the University Psychiatric Hospital and the University of Zurich reveals, ...


Sex, drugs, and rock and roll chemistry in the brain

How brain's own opioids involved in musical pleasure


The same brain-chemical system that mediates feelings of pleasure from sex, recreational drugs, and food is also critical to experiencing musical pleasure, according to a study by McGill University researchers. "This is the first demonstration that the brain's own opioids are directly involved in ...


Scientists reveal non-addictive pathway to pain relief


OHSU research suggests an avenue for developing treatments for chronic pain that harness the medicinal properties of cannabis while minimizing the threat of addiction. The study , conducted in a rodent model, provides additional rationale for the development of therapeutics using cannabinoid ...


Researchers explore epigenetic influences of chronic pain


Despite the enormous societal impact of chronic pain, present treatment options are limited to nonsteroidal anti-inflammatory drugs (NSAIDS), opioids, anticonvulsants and antidepressants, which provide pain relief to only about half of patients. Furthering the problem, prescription opioid ...


Combination drug targeting opioid system may help relieve treatment-resistant depression


A clinical trial of an experimental drug for treatment-resistant major depression finds that modulation of the endogenous opioid system may improve the effectiveness of drugs that target the action of serotonin and related monoamine neurotransmitters. In their paper published online in the ...


Opioid receptor gene variations associated with neonatal abstinence syndrome severity


A study led by researchers at Boston Medical Center (BMC) indicates that variations in opioid receptor genes are associated with more severe neonatal abstinence syndrome (NAS) in newborn babies. The findings, published in Drug & Alcohol Dependence, could help lead to the development of ...


Drug Abuse Triggers Regulations to Push the Development of Tamper-Resistant Opioid Formulations for Pain Management

Targeted pain drugs that do not have side effects such as constipation and addiction have a huge market awaiting them, says Frost & Sullivan


The pain market is currently dominated by opioid analgesics, which have well-known side effects such as addiction and constipation. However, a $10 billion market exists for a company able to develop a novel, targeted pain therapy that excludes these side effects, indicating the huge opportunity ...


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