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74 Current news about the topic oligonucleotides


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New method for producing synthetic DNA

Chemically synthesized short DNA sequences are extremely important ingredients with countless uses


The DNA sequences produced are also called oligonucleotides. These are widely used for disease identification, for the manufacture of oligonucleotide-based drugs, and for several other medical and biotechnological applications. The high demand for oligonucleotides therefore requires an efficient ...


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How to use antibodies to control chemical reactions

Researchers developed a strategy to synthesize functional molecules with specific diagnostic antibodies


Antibodies are remarkable biomarkers: they are the cues that provide us with indications about many diseases and how our immune system counter them. Now a group of scientists from the University of Rome, Tor Vergata (Italy) has found a way to repurpose them so that they can trigger a specific ...


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Evotec and Secarna form strategic partnership in the field of antisense therapy

Comprehensive agreement for the development of novel antisense oligonucleotide therapeutics across a broad range of targets and indications


Evotec SE and Secarna Pharmaceuticals GmbH & Co. KG (Secarna) announced a strategic partnership in the field of antisense oligonucleotide (“ASO”)-based therapeutics. Antisense therapy is an innovative, clinically and commercially validated, highly-targeted pharmacological approach which ...


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New DNA synthesis technique promises rapid, high-fidelity DNA printing


Scientists at the University of California, Berkeley, and Lawrence Berkeley National Laboratory have invented a new way to synthesize DNA that promises to be easier and faster, does not require the use of toxic chemicals and is potentially more accurate. With greater accuracy, the technique could ...


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Programmable drug delivery platform combats diseased cells at genetic level


A new drug delivery system that uses a synthetic-biological hybrid nanocapsule could provide a smart technology for targeted treatment of a variety of serious diseases at the genetic level. The hybrid offers a way to correct diseased cells at the genetic level - while at the same time leaving ...


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Potential 'missing link' in chemistry that led to life on earth found


Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth. Origins-of-life researchers have hypothesized that a chemical reaction called phosphorylation may have been crucial for the assembly of three key ...


Heinrich Emanuel Merck Award for Analytical Science Goes to Professor Francesco Ricci

Recognition of young researchers who develop new methods in chemical analysis


Merck announced that Professor Francesco Ricci from the University of Rome, Tor Vergata, Italy, will receive the 2017 Heinrich Emanuel Merck Award for Analytical Science. The Italian chemist will receive the recognition worth €15,000 for his ground-breaking development of nature-inspired ...


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Gene silencing shows promise for treating 2 fatal neurological disorders


In two studies of mice, researchers showed that a drug, engineered to combat the gene that causes spinocerebellar ataxia type 2 (SCA2), might also be used to treat amyotrophic lateral sclerosis (ALS). "Our results provide hope that we may one day be able to treat these devastating disorders," ...


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New technology offers fast peptide synthesis


Manufacturing small proteins known as peptides is usually very time-consuming, which has slowed development of new peptide drugs for diseases such as cancer, diabetes, and bacterial infections. To help speed up the manufacturing process, MIT researchers have designed a machine that can rapidly ...


FDA Awards Isarna Orphan Drug Designation for ISTH0036 to Improve Glaucoma Treatment Outcome


Isarna Therapeutics announced that the Food and Drug Administration (FDA) has granted orphan drug designation for ISTH0036, a locked nucleic acid-modified antisense oligonucleotide, for the prevention of scarring post glaucoma filtration surgery. The FDA decision follows recently announced EMA ...


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