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433 Current news about the topic metabolic diseases

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New Indication of a Link Between Alzheimer’s and Diabetes

High-resolution 3D model shows strong similarity in the structure of the fibrils

17-Jun-2020

Pathological protein clumps are characteristic of a series of diseases, such as Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Scientists at Forschungszentrum Jülich, Heinrich Heine University Düsseldorf, and Maastricht University have now used cryo-electron microscopy to obtain a ...

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Single-cell RNA seq method developed to accurately quantify cell-specific drug effects in pancreatic islets

Findings could open up potential therapeutic avenues to treat Type 1 diabetes

14-May-2020

Researchers from Stefan Kubicek’s and Christoph Bock’s groups, at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, have developed a method to accurately assess the effect of specific drugs in isolated pancreatic tissue by using a refined single-cell ...

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Beta cells from stem cells: Potential for cell replacement therapy

Quality control with CD177 can help save lots of time, efforts and money

29-Apr-2020

The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation ...

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Evotec regains global rights to beta cell replacement therapy

Evotec continues development of the beta cell programme initially on its own

23-Apr-2020

Evotec SE announced that it will regain global development and commercialisation rights to the iPSC-based programme for the treatment of diabetes developed under collaboration agreement with Sanofi. Evotec has built a unique platform for iPSC-based drug discovery and cell therapy covering the ...

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Sugar leads to early death, but not due to obesity

Study points out that the reduced life expectancy due to sugar consumption could have other causes than previously assumed

24-Mar-2020

We all know that consuming too much sugar is unhealthy. It increases our risk of developing metabolic disorders, such as obesity and diabetes, and can shorten our life expectancy by several years. It is widely believed that this reduction in lifespan is caused by metabolic defects. However, this ...

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Therapies without drugs

Chips and bids taking the place of pills and meds

27-Feb-2020

Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master. A study ...

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New drug combination restores beta cell function in animal model

Potential for diabetes remission

24-Feb-2020

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for ...

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Obesity, heart disease or diabetes could be transmissible

A revolutionary hypothesis

22-Jan-2020

Diseases such as cardiovascular diseases, cancer or certain lung diseases are among the most common non-natural causes of death today and account for about 70 percent of deaths worldwide. They are defined by the World Health Organization (WHO) as non-communicable because they are assumed to be ...

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Looking at the good vibes of molecules: a new method for label-free metabolic imaging

09-Jan-2020

Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...

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Evotec receives € 3 million payment from Sanofi

Evotec achieves third milestone in cell therapy diabetes alliance with Sanofi

20-Dec-2019

Evotec SE announced successful achievement of a third milestone in their diabetes research alliance with Sanofi (“TargetBCD”), resulting in a payment of € 3 m to Evotec. This milestone was triggered after Evotec met pre-agreed critical criteria within the beta cell replacement therapy programme. ...

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