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14 Current news about the topic high-throughput screening


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DESY X-ray lightsource identifies promising candidates for COVID drugs

Existing active substances bind to key virus protein


A team of researchers has identified several candidates for drugs against the coronavirus SARS-CoV-2 at DESY´s high-brilliance X-ray lightsource PETRA III. They bind to an important protein of the virus and could thus be the basis for a drug against Covid-19. In a so-called X-ray screening, the ...


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Looking for a needle in a haystack

TU Dresden's BIOTEC and its PharmAI spin-off analyse millions of active substances that could cure Covid-19


The goal: Identify new drugs for Covid-19 therapy in the fastest possible way, conduct clinical tests and win the battle against the virus. The method: A large-scale research competition that screens billions of molecules in order to find those blocking interactions on SARS-CoV-2, identifying ...


Scientists come up with faster way to discover antibiotics


Russian biochemists have identified a promising new class of antibiotics. Having studied over 125,000 molecules, they found that 2-pyrazol-1-yl-thiazole derivatives exhibit antibacterial properties. One of the discovered compounds has demonstrated a good activity and low cytotoxicity, and thus ...


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Small-volume, high-throughput organic synthesis

New method synthesizes and evaluates large number of drug leads


University of Groningen Professor of Drug Design, Alexander Dömling, has devised a method to rapidly synthesize thousands of new molecules and evaluate their properties as potential drugs. In a paper published by Science Advances on 5 July, he shows that this method works well when applied to ...


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Fleming’s method in miniature


Scientists in the Department of Biosystems Science and Engineering at ETH Zurich in Basel have developed a method with which they can quickly test a very large number of molecules for antibiotic effect. With it, they have already successfully discovered new antibiotic candidates produced by ...


New screening tool could speed development of ovarian cancer drugs


University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis. Their three-dimensional cell-culture system, adapted for high-throughput screening, has enabled ...


A universal Ebola drug target

New study reports design, characterization of universally conserved drug target for current, future strains of virus


University of Utah biochemists have reported a new drug discovery tool against the Ebola virus. According to a study published in Protein Science, they have produced a molecule, known as a peptide mimic, that displays a functionally critical region of the virus that is universally conserved in ...


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Novel anti-malarial drug target identified


An international team of scientists, led by researchers from the Department of Pediatrics at the University of California, San Diego School of Medicine, have identified the first reported inhibitors of a key enzyme involved in survival of the parasite responsible for malaria. Their findings, ...


Cancer Therapeutics reveals proof of concept for second development drug


Cancer Therapeutics announced the validation and performance of a new targeted drug, CTx-294886, in combination with Avastin™ (bevacizumab – Genentech/Roche) in a preclinical model of breast cancer. At the same time the Company announced that it has developed a new High Throughput Screening (HTS) ...


Proteros and University of Cincinnati, Drug Discovery Center establish collaboration to offer high-throughput screening services


Proteros Biostructures GmbH announced that it has entered into an agreement with University of Cincinnati, Drug Discovery Center (UC DDC), under which Proteros will provide biotech and pharmaceutical companies with access to UC DDC’s ultra-high-throughput and high-content screening platform ...


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