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10 Current news about the topic heterochromatin

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The world's tiniest first responders

'Walking molecules' haul away damaged DNA to the cell's emergency room

22-Jun-2018

The cell has its own paramedic team and emergency room to aid and repair damaged DNA, a new USC Dornsife study reveals. The findings are timely, as scientists are delving into the potential of genome editing with the DNA-cutting enzyme, CRISPR-Cas9, to treat diseases or to advance scientific ...

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New mechanism for genome regulation found

23-Jun-2017

The same mechanisms that quickly separate mixtures of oil and water are at play when controlling the organization in an unusual part of our DNA called heterochromatin, according to a new study by researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley ...

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Laser pulses reveal DNA repair mechanisms

A new straightforward method enables monitoring the response of nuclear proteins to DNA damage in time and space

14-Aug-2013

Understanding the cellular response to DNA strand breaks is crucial to decipher the mechanisms maintaining the integrity of our genome. In eukaryotic cells, the molecular events triggered by DNA damage are strongly influenced by the local chromatin environment surrounding the lesion. The ensuing ...

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Making and breaking heterochromatin

Scientists discover 2 further mechanisms necessary for the formation of heterochromatin

28-Sep-2012

To fit the two-meter long DNA molecule into a cell nucleus that is only a few thousandths of a millimetre in size, long sections of the DNA must be strongly compacted. Epigenetic marks maintain these sections, known as heterochromatin. Scientists of the Max Planck Institute of Immunobiology and ...

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How yeast chromosomes avoid the bad breaks

09-Aug-2011

The human genome is peppered with repeated DNA elements that can vary from a few to thousands of consecutive copies of the same sequence. During meiosis—the cell division that produces sperm and eggs—repetitive elements place the genome at risk for dangerous rearrangements from genome ...

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Mechanism for stress-induced epigenetic inheritance uncovered in new study

European Marketing Authorization Application (MAA) expected by the end of 2011

27-Jun-2011

Researchers at RIKEN have uncovered a mechanism by which the effects of stress in the fly species Drosophila are inherited epigenetically over many generations through changes to the structure of chromatin, the material that makes up the cell nucleus. Published in the journal Cell, the results ...

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A solution to Darwin's 'mystery of the mysteries' emerges from the dark matter of the genome

28-Oct-2009

Biological species are often defined on the basis of reproductive isolation. Ever since Darwin pointed out his difficulty in explaining why crosses between two species often yield sterile or inviable progeny (for instance, mules emerging from a cross between a horse and a donkey), biologists have ...

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"Silent" fungus metabolism awakened for new natural products

Fungi wake up to new natural products

06-May-2008

US scientists have re-awakened 'silent' metabolic pathways in fungi to reveal a new range of natural products. The research could provide not only a source of new drugs, but a way to "listen to what fungi are saying" to organisms around them. Fungi produce a wide variety of natural products, ...

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Scripps Research Team Reverses Friedreich's Ataxia Defect in Cell Culture

Newly Developed Compounds Activate Silenced Gene Responsible for Debilitating Disease

24-Aug-2006

A team from The Scripps Research Institute and the University of California School of Medicine has developed compounds that reactivate the gene responsible for the neurodegenerative disease Friedreich's ataxia, offering hope for an effective treatment for this devastating and often deadly ...

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Scientists Describe Structural Basis of DNA's 'Second Code'

Findings Published in Nature

26-Jul-2004

Orion Genomics, a "second code" biotechnology company developing and commercializing oncology diagnostic products, announced that research conducted by the company's scientific co-founder Rob Martienssen, professor at Cold Spring Harbor Laboratory, has advanced understanding of the epigenetic ...

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