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New approaches for future cancer treatments
02-Nov-2017 - How can defective gene activity, which can ultimately lead to cancer, be avoided? Researchers at the University of Zurich have now identified a mechanism how cells pass on the regulation of genetic information through epigenetic modifications. These insights open the door to new approaches for ...
18-Sep-2017 - Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any other time. Researchers have long assumed that genes become "silent" during ...
29-Aug-2017 - "Infertility affects 10 to 15 percent of couples in the United States, with the vast majority of cases due to unknown causes. Approximately 40 percent of these cases are due to male infertility," said senior author Khalil. Khalil and colleagues have been working to understand genetic mechanisms ...
19-Jul-2017 - Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases. The key is to be able to intervene during ...
29-Jun-2017 - Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai. Mount Sinai researchers led an international, genome-wide study of more than 40,000 people ...
Wasp venom offers new insights
26-Jun-2017 - Amid the incredible diversity of living things on our planet, there is a common theme. Organisms need to acquire new genes, or change the functions of existing genes, in order to adapt and survive. How does that happen? A common view is that genes duplicate, with one of the copies picking up a ...
22-May-2017 - After decades of research aiming to understand how DNA is organized in human cells, scientists at the Gladstone Institutes have shed new light on this mysterious field by discovering how a key protein helps control gene organization. Humans have nearly 30,000 genes that determine traits from eye ...
24-Apr-2017 - DNA molecules in the cells‘ nuclei are neatly folded into loops. This serves to wrap them up tightly, but also to bring distant gene regulatory sequences into close contact. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna describe how cohesin might do the trick. Twenty ...
Stem cell factor Nanog knows when to slow down
28-Nov-2016 - The transcription factor Nanog plays a crucial role in the self-renewal of embryonic stem cells. Previously unclear was how its protein abundance is regulated in the cells. Researchers at the Helmholtz Zentrum München and the Technical University of Munich, working in collaboration with ...
RNA-based gene regulation with dynamic proteins
07-Nov-2016 - Before RNA transcripts of genes can program the synthesis of proteins, the non-coding regions are removed by the spliceosome, a complex molecular machine. The correct regulation of the splicing plays a central role for many cellular processes. By means of nuclear magnetic resonance measurements ...
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