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46 Current news about the topic chronic lymphocytic leukemia

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Tracing the path of leukemia

Chemical signature of chronic lymphocytic leukemia already present in the precancerous stage

26-Jan-2021

B-cell lymphocytosis, a condition in which individuals have increased levels of particular white blood cells, in some cases leads to blood cancer. As an international team of researchers now shows in samples from patients, both diseases exhibit similar epigenetic signatures that are forming very ...

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A potent weapon against lymphomas

Mice with leukemia were cured

19-Jan-2021

MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults. The ...

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A potential new target for immunotherapies in cancer

Compounds that inhibit metabolic enzyme IL4I1 could open up new opportunities for cancer therapy

24-Aug-2020

The metabolic enzyme IL4I1 (interleukin-4-induced-1) promotes the spread of tumor cells and suppresses the immune system. This was discovered by scientists from the Berlin Institute of Health (BIH) together with colleagues from the German Cancer Research Center (DKFZ) in Heidelberg. The enzyme is ...

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A combination drug trial to eradicate B-cell malignancies launched

13-Mar-2018

Fueled by a multimillion dollar grant from the state's stem cell agency, researchers at University of California San Diego School of Medicine, in collaboration with local biotechnology company Oncternal Therapeutics, have launched a phase Ib/II clinical trial to evaluate the combined ...

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New driver, target in advanced mucosal melanoma

16-Mar-2017

Not all melanomas are created equal. While most melanomas appear on the skin as the result of sun exposure, a small subset of melanomas arise spontaneously from mucosal tissues. And while targeted treatments and immunotherapies have dramatically improved the prognosis for many patients with ...

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Clinical Trial Results Show New Drug is Better for CLL Patients

08-Dec-2015

Older adults with chronic lymphocytic leukemia may now have an alternative to toxic chemotherapy as their first treatment, according to a national study by a UR Medicine Wilmot Cancer Institute oncologist and reported in the New England Journal of Medicine. The phase 3 clinical trial compared a ...

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Phase 2 Study of Venetoclax in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Meets Primary Endpoint

19-Aug-2015

AbbVie announced that a Phase 2 trial of its investigational medicine venetoclax met its primary endpoint of achievingoverall response rates in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia (CLL) with 17p deletion, according to an independent review ...

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European Medicines Agency recommends approval of two new treatment options for rare cancers

Imbruvica and Zydelig to be used in different forms of blood cancers

04-Aug-2014

The European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP), at its July meeting, recommended granting marketing authorisations for two new medicines with novel mechanisms of action for the treatment of different forms of rare cancers of the blood. Imbruvica ...

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European Medicines Agency recommends approval of Gazyvaro for chronic lymphocytic leukaemia

Medicine represents new treatment option for patients with rare life-threatening disease

28-May-2014

The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended marketing authorisation for Gazyvaro (obinutuzumab) in combination with the cancer medicine chlorambucil for the treatment of adults with previously untreated chronic lymphocytic ...

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Molecular robots can help researchers build more targeted therapeutics

Study demonstrates technique to create better anti-cancer agents, arthritis drugs, and more

31-Jul-2013

Many drugs such as agents for cancer or autoimmune diseases have nasty side effects because while they kill disease-causing cells, they also affect healthy cells. Now a new study has demonstrated a technique for developing more targeted drugs, by using molecular "robots" to hone in on more ...

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