Adrenomedullin causes diabetes in overweight people

The hormone triggers insulin resistance in blood vessel endothelium in obesity

13-Feb-2025 - A large proportion of the approximately six million patients in Germany suffering from type 2 diabetes are overweight. The effect of insulin is impaired in these patients. The cause of this insulin resistance has been sought primarily in metabolically active organs for a long time. Researchers at ...

"Anti-obesity drugs" normalises brain in obesity

Anti-obesity drug improves associative learning in people with obesity

22-Aug-2023 - Obesity leads to altered energy metabolism and reduced insulin sensitivity of cells. The so-called "anti-obesity drugs" are increasingly used to treat obesity and have caused tremendous interest, especially in the USA. Researchers at the Max Planck Institute for Metabolism Research in Cologne, ...

Study opens up new possibilities to improve health in old age

Insulin influences life expectancy: Sex-specific differences in response to reduced insulin activity

28-Feb-2023 - Insulin is not only a regulator of blood sugar, but also has an influence on life expectancy. If the insulin signalling pathway is inhibited, animals live longer. But which tissue is crucial for this? And do males and females react in the same way? Researchers from the Max Planck Institute for ...

Insulin strengthens the intestinal barrier and protects against colorectal cancer

08-Mar-2019 - Excess weight promotes the development of insulin resistance and the incidence of colon cancer. Scientists from the Max Planck Institute for Metabolic Research in Cologne identified a new mechanism of the insulin signalling in the intestinal mucosa, which is responsible for maintaining the ...

A fingerprint for genes

Max Planck scientists develop new strategy to play major role in research on human diseases

09-Mar-2010 - Cells may not have a mouth, but they still need to ingest substances from the external environment. If this process - known as endocytosis - is affected, it can lead to infectious diseases or cardio-vascular diseases, cancer, Huntington’s and diabetes. In cooperation with the Center for ...