New muscle therapy gets fast-track boost

Berlin start-up could soon be helping children with previously incurable muscle diseases thanks to an accelerated approval process

01-Aug-2023 - To help bring therapies for rare muscle diseases in children to market sooner, the Berlin-based start-up MyoPax, a spin-off from the Max Delbrück Center and Charité – Universitätsmedizin Berlin, has now received a boost from the U.S. Food and Drug Administration (FDA). The company has been ...

NIH clinical trial of remdesivir to treat COVID-19 begins

27-Feb-2020 - A randomized, controlled clinical trial to evaluate the safety and efficacy of the investigational antiviral remdesivir in hospitalized adults diagnosed with coronavirus disease 2019 (COVID-19) has begun at the University of Nebraska Medical Center (UNMC) in Omaha. The trial regulatory sponsor is ...

Investigational monoclonal antibody to treat Ebola is safe in adults

28-Jan-2019 - The investigational Ebola treatment mAb114 is safe, well-tolerated, and easy to administer, according to findings from an early-stage clinical trial. Eighteen healthy adults received the monoclonal antibody as part of a Phase 1 clinical trial that began in May 2018 at the National Institutes of ...

CureVac enters clinical phase with mRNA vaccine

First data expected on intramuscular application of the newly developed vaccine

25-Oct-2018 - CureVac AG, a fully integrated biopharmaceutical company pioneering the field of mRNA-based drugs, today announced the initiation of its Phase I dose-escalation clinical trial with the novel mRNA-based rabies vaccine, CV7202. This is the first-in-human clinical trial of CureVac’s naturally ...

Fresh insights into light-activated cancer drugs

15-Feb-2018 - Cancer drugs activated by light, minimizing toxic side-effects, are a step closer thanks to new research from University of Warwick and Monash University through the Monash Warwick Alliance Platinum-based chemotherapy drug candidate kills cancer cells in specific targeted areas, and totally ...

New drug combination helps kickstart the immune system to fight back against cancer

19-Jan-2018 - Scientists from King's College London have found a way to boost the immune system to help it fight back against cancer. The breakthrough involves the first ever use of a combination of chemotherapy and a drug being trialled as a treatment for neonatal jaundice, that together help kick start the ...

Alzheimer's drug turns back clock in powerhouse of cell

11-Jan-2018 - The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. They report that the drug binds to ...

Key discoveries offer significant hope of reversing antibiotic resistance

23-Oct-2017 - Resistance to antibiotics is becoming increasingly prevalent and threatens to undermine healthcare systems across the globe. Antibiotics including penicillins, cephalosporins and carbapenems are known as β-lactams and are the most commonly prescribed worldwide. In the first paper, University of ...

Simple Biomechanical Test could aid Implant Success

Deeper insight into potential interaction between implants and body tissues

11-Oct-2017 - The quality of the tissue-implant interface is key to the success of implant integration. High-output benchtop screening can help developers in assessing the complex interplay between biomaterials and the body to better prepare for clinical trials.High-output screening aims to maximize the amount ...

FDA approval brings first gene therapy to the United States

01-Sep-2017 - The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases. The FDA approved Kymriah (tisagenlecleucel) for certain ...