Immune Targeting Systems announces positive Phase I data for its pan-strain influenza A T-cell vaccine

19-Sep-2012 - United Kingdom

Immune Targeting Systems Limited (“ITS”) announced compelling data from two Phase I clinical trials of FlunisynTM, the Company’s lead vaccine programme which elicits potent immune responses against multiple strains of influenza-A virus. ITS also announces the appointments of Dr. Benjamin Chen, Executive Chairman and Dr. Kevin FitzGerald, Chief Operating Officer, to support the Company as it moves towards commercialisation of its products and technologies.

The first Phase I trial showed that FlunisynTM generated statistically significant cell-mediated immune responses to the vaccine and was safe and well tolerated in vaccinated groups compared to placebo. The trial was a randomised, double-blind, placebo-controlled, escalating dose study in 48 healthy adult volunteers.

The second trial was a randomised, double blind study to compare the immunogenicity of FlunisynTM, alone or with an undisclosed adjuvant, in 48 healthy adult volunteers. Both formulations generated strong cell-mediated immunity but with the adjuvant formulation generating enhanced responses.

From both trials, the T-cell responses induced by FlunisynTM were able to recognise multiple strains of influenza A.

Dr. Campbell Bunce, ITS’ Research Director, commented: “From these Phase I data, we are extremely encouraged to see that FlunisynTM induces strong, pan-strain, immune responses that have the potential to protect the population against the severe and sometimes fatal symptoms of influenza infection. Additionally, the magnitude of the immune response that was induced by Flunisyn™ is unprecedented for a peptide based approach, with or without the use of adjuvants.”

https://www.bionity.com/en/news/139771/immune-targeting-systems-announces-positive-phase-i-data-for-its-pan-strain-influenza-a-t-cell-vaccine.html