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News Inflammation

  • Anti-inflammatory drug protects against lethal inflammation from COVID-19 in animal models

    Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19. In a study published today in the journal Cell, the team reported that the drug, Topoteca more

  • Bats offer clues to treating COVID-19

    Bats are often considered patient zero for many deadly viruses affecting humans, including Ebola, rabies, and, most recently, the SARS-CoV-2 strain of virus that causes coronavirus. Although humans experience adverse symptoms when afflicted with these pathogens, bats are remarkably able to tolerate more

  • Age-related impairments reversed in animal model

    Frailty and immune decline are two main features of old age. Researchers from the University of Bern and the University Hospital Bern now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach. Eld more

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The Chemistry of Stinging Nettles

Doubtless the majority of people reading this will, at some point in their life, have had the unpleasant experience of being stung by stinging nettles. But what chemicals do stinging nettles contain that elicit this effect? Further to that, a commonly espoused remedy for the stings, in the UK at lea more

Publications Inflammation

  • Inflammatory decoy control

    Sepsis Bacterial infection can lead to sepsis, inflammation, and death. Li et al. found that the long noncoding RNA MEG3-4 and the mRNA encoding the proinflammatory cytokine interleukin-1β (IL-1β) competitively bound to the microRNA miR-138 in the lungs of bacterially infected mice. Initially, more

  • Controlled activation

    T Cell Activation At the intestinal barrier, lymphocyte activation is a tightly regulated process that enables rapid responses to pathogens but avoids destructive inflammation. Konjar et al. examined how intraepithelial lymphocytes (IELs) maintain a controlled activation state, which is influenced more

  • Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor [Immunology and Inflammation]

    The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases-1, -4, -5, and -11, which cleave gasdermin D (GSDMD) to induce pyroptotic cell death. The mechanisms of GSDMD recognition by inflammatory caspases remain poorly understood. Here, we demons more

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Inflammation on the skin, showing the redness and swelling characteristic of inflammation (presents as darkening in people with dark skin). Black rings of necrotic tissue surround central areas of pus Inflammation (Latin , inflammatio, to set ... more


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