How does the immune system age?

Research team shows very precise and comprehensive correlation between immune profiles and age, gender, smoking, obesity and diseases

09-Apr-2025 - Why are older people more susceptible to infections than younger people? Why do vaccinations sometimes have less of an effect on them? In order to better understand the mechanisms of the ageing immune system, the RESIST-Senior Individuals Cohort was set up as part of the Cluster of Excellence ...

Structure of central inflammation switch elucidated

Study could provide medicine with a powerful therapeutic tool

07-Feb-2022 - Researchers at the Universities of Bonn and Regensburg have elucidated the structure of a central cellular inflammatory switch. Their work shows which site of the giant protein called NLRP3 inhibitors can bind to. This opens the way to develop new pharmaceuticals that could target inflammatory ...

A way to synthesize drugs from renewable precursors

16-Nov-2017 - The scientists of RUDN University together with their Russian colleagues have developed a new approach to the synthesis of benzofurans from cheap raw materials. Original furans can be produced from wastes of agriculture and wooworking industry, such as sawdust, cobs and other by-products of crop ...

How crystals precipitate cell death

01-Feb-2016 - Crystal formation plays a defining role in the pathogenesis of a range of common diseases, such as gout and atherosclerosis. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Hans-Joachim Anders have now elucidated how the insoluble deposits induce cell death. The formation of ...

Vitamin C does not lower uric acid levels in gout patients

17-May-2013 - Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout. Vitamin C supplementation, alone or in combination ...

Novartis awards 2010 Prizes for Immunology in recognition of outstanding contributions to immunology in medical research

25-Aug-2010 - The Novartis 2010 Immunology Prizes were presented at the 16th International Congress of Immunology in Kobe, Japan. Since 1992, the Novartis Prizes for Immunology have been awarded every third year for outstanding contributions to basic and clinical immunology. The prizes recognize individual ...

New Phase II study in gout patients shows Novartis ACZ885 prevented acute flares better than standard anti-inflammatory therapy

22-Jun-2010 - New phase II data demonstrate that the human monoclonal antibody ACZ885 (also known as canakinumab) provided highly statistically significant risk reduction of acute flares in gout patients initiating uric acid lowering therapy (UALT) compared to the anti-inflammatory standard of care ...

New Phase II data show Novartis' ACZ885 gave better pain relief and flare prevention for patients with chronic gout

22-Oct-2009 - New Phase II results show that the novel biological therapy ACZ885 (canakinumab) is significantly more effective than an injectable corticosteroid at reducing pain and preventing recurrent attacks or 'flares' in patients with hard-to-treat gout, one of the most painful forms of arthritis. The ...