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Thrombophilia is the propensity to develop thrombosis (blood clots) due to an abnormality in the system of coagulation.
Additional recommended knowledge
Searching for a coagulation abnormality is not normally undertaken in patients in whom thrombosis has an obvious other cause. For example, if the thrombosis is due to immobilisation after recent orthopedic surgery, it is unlikely that an underlying cause is found.
Conversely, although thrombosis itself may occur in any person, repeated (two or more) unprovoked episodes of thrombosis and unusual sites and types of thrombosis (e.g. Budd-Chiari syndrome) may point towards a coagulation disorder.
Increasingly, recurrent miscarriage is seen as an indication for thrombophilia screening. 
Thrombophilia can be classified in various forms.
Tests for thrombophilia include prothrombin time and INR, partial thromboplastin time, thrombin time, fibrinogen levels, antiphospholipid antibody levels (IgG- and IgM-anticardiolipin, dilute Russell viper venom time and lupus anticoagulant), protein C, protein S and antithrombin (both levels and activity), activated protein C resistance (APC resistance), factor V Leiden and prothrombin mutation. Many laboratories add on various other tests, depending on local policy and guidelines.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thrombophilia". A list of authors is available in Wikipedia.|