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Specific inhalation challenge



The Specific Inhalation Challenge (SIC) is defined as a diagnosis tool to assess airway responsiveness to "sensitizing" substances as opposed to nonspecific stimuli such as pharmacological agents (i.e. histamine, methacholine), cold air and exercise.[1] Subjects are exposed to a suspected occupational agent in a controlled way under close supervision in a hospital laboratory. The specific inhalation challenges has been considered as the gold standard in confirming the diagnosis of occupational asthma. [2]

Contents

SIC methods

One of the steps of SIC is to perform a challenge with the suspected asthmagen. Then, FEV1 is subsequently measured using another device and compared to a baseline. A positive response is usually a decrease in baseline FEV1 of 15 to 20 percent.

Realistic Method

The Realistic Method was developed in the 1970's.[3] The patient enters a sealed chamber and is exposed to the suspected agent in a controlled, non-work, test environment. The asthmagen can be water-soluble and nebulized. If the agent is non-soluble, the patient tips the agent from one tray to another in an attempt to mimic the work environment. This method has the advantage of being able to assess, albeit highly subjectively, ocular and nasal symptoms as well as a reduction in FEV1.[4]

There are, however, disadvantages to the method. First, SIC is currently only conducted in specialty facilities because the facilities and equipment are rare and expensive. Second, the realistic method may exposed the patient to huge concentrations of particles, resulting in unduly severe asthma attacks.[5] Alternately, the agent can be delivered using the recently developed closed-circuit technique.

Closed-Circuit Method

This test requires the patient to breathe aerosols of the suspected agent (asthmagen) through an oro-facial mask or mouth piece. These asthmagens are aerosolized using closed-circuit chambers, and the quantities and concentrations administered being minute and extremely stable minimize the risk of exaggerated responses.[6]

References

  1. ^ Vandenplas and Malo, 1997 Vandenplas O, Malo JL. Inhalation challenges with agents causing occupational asthma. Eur Respir J 1997; 10:2612-29.
  2. ^ Cloutier et al., 1992 Cloutier Y, Lagier F, Cartier A, Malo JL. Validation of an exposure system to particles for the diagnosis of occupational asthma. Chest 1992; 102: 402–407.
  3. ^ Occupational Asthma: The Past 50 years Chan-Yeung M. Jan/Feb 2004, Volume 11, Number 01: 21-26
  4. ^ Occupational Asthma: The Past 50 years Chan-Yeung M. Jan/Feb 2004, Volume 11, Number 01: 21-26
  5. ^ Cloutier et al., 1989 Cloutier Y, Lagier F, Lemieux R, Blais MC, St-Arnaud C, Cartier A, and Malo JL. New methodology for specific inhalation challenges with occupational agents in powder form. Eur Respir J 1989; 2: 769-777.
  6. ^ Malo et al., 2004 Malo JL, Cartier A, Lemiere C, Desjardins A, Labrecque M, L'Archeveque J, Perrault G, Lesage J, Cloutier Y. Exaggerated bronchoconstriction due to inhalation challenges with occupational agents. Eur Respir J 2004; 23: 300–303.

See also

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Specific_inhalation_challenge". A list of authors is available in Wikipedia.
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