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Smart ligands are affinity ligands selected with pre-defined equilibrium (Kd), kinetic (koff, kon) and thermodynamic (ΔH, ΔS) parameters of biomolecular interaction.
Additional recommended knowledge
Ligands with desired parameters can be selected from large combinatorial libraries of biopolymers using instrumental separation techniques with well-described kinetic behaviour, such as Kinetic Capillary Electrophoresis (KCE), Surface Plasmon Resonance (SPR) and etc. Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed.
Smart ligands can find a set of unique applications in biomedical research, drug discovery and proteomic studies. For example, a panel of DNA smart aptamers has been recently used to develop affinity analysis of proteins with ultra-wide dynamic range of measured concentrations.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Smart_ligands". A list of authors is available in Wikipedia.|