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Rous sarcoma virus
Rous sarcoma virus is a retrovirus; a class VI enveloped virus with a positive sense RNA genome having a DNA intermediate. As with all retroviruses, it reverse transcribes its RNA genome into cDNA before integration into the host DNA.
Additional recommended knowledge
The RSV genome has terminal repeats enabling its integration into the host genome and also over expression of RSV genes.
RSV was discovered in 1916 by Peyton Rous, working at Rockefeller University in New York City, by injecting cell free extract of chicken tumour into healthy chickens.
The extract was found to induce oncogenesis in Plymouth Rock chickens. The tumour was found to be composed of connective tissue (a sarcoma).
Rous was awarded the Nobel Prize for the significance of his discovery in 1966.
RSV has four genes:
The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells. It is an acquired gene, found to be present throughout the animal kingdom with high levels of conservation between species.
The src gene was taken up by RSV and incorporated into its genome conferring it with the advantage of being able to stimulate uncontrolled mitosis of host cells, providing abundant cells for fresh infection.
The src gene is not essential for RSV proliferation but it greatly increases virulence when present.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rous_sarcoma_virus". A list of authors is available in Wikipedia.|