To use all functions of this page, please activate cookies in your browser.
My watch list
my.bionity.com
my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
PIP2PIP2 or Phosphatidylinositol bisphosphate is general term that refers to the products obtained by cleavage of PIP3. Additional recommended knowledgePIP2 is a substrate for cleavage with phospholipase C, a membrane-bound enzyme activated through α1 adrenergic receptors. Products of this reaction are inositol triphosphate (IP3) and diacylglycerol (DAG). In this cascade, DAG remains in the cellular matrix and activates the signal cascade by activating protein kinase C (pKc). PKc in turn activates other cytosolic proteins by phosphorylating the protein. The effect of pKc can be reversed by phosphodiesterases. IP3 one is an intracellular second messenger that activates calcium channels on smooth ER, allowing calcium ion diffusion into the cytosol. Calcium helps the cascade by activating other proteins. See also Phosphatidylinositol (3,4)-bisphosphate Phosphatidylinositol (4,5)-bisphosphate Phosphatidylinositol (3,5)-bisphosphate
|
||||||||
| This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "PIP2". A list of authors is available in Wikipedia. | ||||||||
