My watch list  


Classification & external resources
ICD-9 251.9
OMIM 601820 256450
DiseasesDB 8922
eMedicine ped/1565 
MeSH D046768

Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive function of pancreatic beta cells with an abnormal microscopic appearance. The term was coined in the first half of the 20th century. The abnormal histologic aspects of the tissue included the presence of islet cell enlargement, islet cell dysplasia, beta cells budding from ductal epithelium, and islets in apposition to ducts.

By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1970s, it was used as a synonym for what is now referred to as congenital hyperinsulinism. Most congenital hyperinsulinism is caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features were sometimes seen in pancreatic tissue from normal infants and even adults, and is not consistently associated with hyperinsulinemic hypoglycemia.

However, the term has been resurrected in recent years to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery.[1][2][3]

See also


  1. ^ Raffel A, Krausch M M, Anlauf M, Wieben D, Braunstein S, Klöppel G, Röher H, Knoefel W (2007). "Diffuse nesidioblastosis as a cause of hyperinsulinemic hypoglycemia in adults: a diagnostic and therapeutic challenge". Surgery 141 (2): 179-84; discussion 185-6. PMID 17263973.
  2. ^ Clancy T, Moore F, Zinner M (2006). "Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia". J Gastrointest Surg 10 (8): 1116-9. PMID 16966030.
  3. ^ Raffel A, Anlauf M, Hosch S, Krausch M, Henopp T, Bauersfeld J, Klofat R, Bach D, Eisenberger C, Kloppel G, Knoefel W (2006). "Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes". World J Gastroenterol 12 (44): 7221-4. PMID 17131493.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nesidioblastosis". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE