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Micronucleus test

A micronucleus test is a test used in toxicological screening for potential genotoxic compounds. In vitro culture cells are checked for induced micronucleus formation.

A micronucleus is the erratic (third) nucleus that is formed during the anaphase of mitosis.

Using fluorescent in situ hybridization (FISH) with probes targeted to the centromere region, it can be determined if a whole chromosome, or only a fragment is lost.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Micronucleus_test". A list of authors is available in Wikipedia.
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