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Memory consolidation, broadly defined, is the process by which recent memories (short-term memories) are crystallised into long-term memory. The term "consolidation" is used to refer to different levels of organization:
Additional recommended knowledge
Reconsolidation is the process of once again consolidating memories which are actively being recalled (such recalled memories have already been previously consolidated). It involves neural processes that are similar to those involved in the original consolidation. In laboratory animals, recall puts memories into an unstable labile state, and after recall, the memory must be reconsolidated or it will be forgotten. Memory reconsolidation occurs upon review or repetition of the learned material.
Both consolidation and reconsolidation can be disrupted by pharmacological agents (e.g. the protein synthesis inhibitor anisomycin) and both require the transcription factor CREB. Recent research suggests that BDNF is required for consolidation (but not reconsolidation) whereas the transcription factor and immediate early gene Zif268 is required for reconsolidation but not consolidation. Memory reconsolidation may also be disrupted by blocking NMDA receptors.
Research papers of interest
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Memory_consolidation". A list of authors is available in Wikipedia.|