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Melanocortins are a group of pituitary peptide hormones that include adrenocorticotropin (ACTH) and the alpha, beta and gamma melanocyte-stimulating hormones (MSH) that derive from the prohormone proopiomelanocortin.
Additional recommended knowledge
Melanocortins act through a multitude of melanocortin receptors designated MC1 through MC5. MC2 is also known as the adrenocorticotrophic hormone receptor since it selectively binds ACTH. The other melanocortin receptors are semi-selective in their ability to bind multiple melanocortins to some degree.
Several synthetic melanocortins are in development including Clinuvel's CUV1647 (Melanotan) for sunless tanning and Palatin Technologies' bremelanotide for erectile dysfunction and sexual arousal disorder.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Melanocortin". A list of authors is available in Wikipedia.|