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Loin pain hematuria syndrome
Additional recommended knowledge
LPHS is considered a diagnosis of exclusion as hematuria (blood in the urine) and flank pain can result from a number of causes.
Relation to chronic pelvic pain
Relation to thin basement membrane disease
The condition is very rare and predominately affects females. Worldwide, only several hundred cases have been reported.
The cause of LPHS is currently not known. One theory proposes that it is caused by a thin glomerular basement membrane and red blood cell (RBC) renal tubular congestion that leads to swelling of the kidney and distension of the renal fascia resulting in pain.
The treatment of LPHS varies considerably from centre to centre. As the condition is rare and poorly understood a widely adopted standard of care is not existent.
Pain management with opiate and non-opiate analgesia is common. Angiotensin converting enzyme inhibitors are thought to be beneficial, as they reduce intraglomerular pressure and, presumably, reduce renal tubular congestion with RBCs.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Loin_pain_hematuria_syndrome". A list of authors is available in Wikipedia.|