Letterer-Siwe disease

Letterer-Siwe disease is a condition where histiocytes proliferate in the body. It is sometimes classified as a form of Langerhans cell histiocytosis, or as a diseminated form of histiocytosis X. It is most commonly seen in children less than two years old.

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Symptoms include lymphadenopathy, hepatosplenomegaly, and seborrhea-like lesions on the skin. Untreated, the disease is fatal. The five-year survival rate with treatment is fifty percent.

See also

• Histiocytosis