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Food preservative work
In 1934, Stone, while director of the enzyme and fermentation research laboratory for the Wallerstein Company, worked on the antioxidant properties of ascorbate (also known as Vitamin C), which had then recently been described by Albert Szent-Györgyi only two years earlier.
He discovered he could use ascorbate to keep foodstuffs fresh for longer, limiting the effects of exposure to air and oxidation. Stone obtained the first patents on an industrial application of ascorbic acid with three patent applications filed in 1935 and granted in 1939 and 1940. 
Dr. Stone’s research in ascorbic acid continued and led to his interest in the disease, scurvy. By the late 1950’s, Stone had formulated his hypothesis that scurvy was not a dietary disturbance, but a potentially fatal flaw in human genetics that had suppressed an essential part of the mammalian biochemistry and had been misunderstood by nutritionists. He proposed the name hypoascorbemia for the effects of this genetic defect. He proposed that ascorbate was not a vitamin required only in trace amounts, but was required by humans in relatively large daily quantities. He produced four papers, between 1965 and 1967, describing what he considered the true human requirement for ascorbate . 
Stone experienced great difficulty in getting his ideas published. However, following his retirement from his position as chemist from the Wallerstein company, in 1971, he worked full time on ascorbate. He published numerous papers and a book, The Healing Factor, in 1972. Irwin Stone introduced Linus Pauling to Vitamin C and is recognised within orthomolecular medicine as one of its founders.  His research provided additional scientific background for the clinical results of megadose ascorbate treatments claimed by his contemporary, Dr Fred R. Klenner. 
Both Linus Pauling and Albert Szent-Györgyi wrote forwards to The Healing Factor endorsing his ideas. 
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Irwin_Stone". A list of authors is available in Wikipedia.|