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Interleukin 35 (IL-35) is an IL-12 family cytokine which is expressed in regulatory but not effector T cells. It is a dimer composed of IL-12α and IL-27β chains, encoded by two separate genes. Knock-out mice for either of these two genes (Ebi3 and IL12a, respectively) show no overt autoimmunity, but IL-12α and IL-27β knockout T regulatory cells are unable to suppress effectively in vitro or in an inflammatory bowel disease model. The Ebi3 gene also seems to be a direct target of the transcription factor Foxp3.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_35". A list of authors is available in Wikipedia.|